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dc.contributor.authorKalmodia, S
dc.contributor.authorSon, KN
dc.contributor.authorCao, D
dc.contributor.authorLee, BS
dc.contributor.authorSurenkhuu, B
dc.contributor.authorShah, D
dc.contributor.authorAli, M
dc.contributor.authorBalasubramaniam, A
dc.contributor.authorJain, S
dc.contributor.authorAakalu, VK
dc.date.accessioned2020-04-23T03:03:05Z
dc.date.available2020-04-23T03:03:05Z
dc.date.issued2019
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/s41598-019-46623-9
dc.identifier.urihttp://hdl.handle.net/10072/393357
dc.description.abstractThe aims of this study were to determine if histatin-1 (H1) is present in normal human tears and whether tear levels of H1 varied between normal patients and those with aqueous deficient dry eye disease (ADDE). Patient samples were obtained from 11 normal patients and 11 severe ADDE patients. Relevant patient characteristics, including age, sex, and dry eye disease (DED) diagnostic parameters were collected. Multiple qualitative and quantitative methods were used to compare the concentration of H1 between patient groups. Mixed linear modeling was used to compare H1 levels between groups, and diagnostic performance was assessed using the receiver-operator-characteristic (ROC). ADDE patients had significantly lower H1 concentrations (85.9 ± 63.7 ng/ml) than the normal group (891.6 ± 196.5 ng/ml) (p < 0.001), while controlling for age and sex. ROC analysis indicated that H1 concentration is potentially a biomarker for ADDE (area under curve = 0.96). Reclassification of patients by DED parameters including, Ocular Surface Disease Index (OSDI) (≤13, >13) and Schirmer I (without anesthesia) (<10 mm, ≥10 mm) showed significant differences in H1 level (OSDI, p = 0.004) and Schirmer I ((p = 0.010). In conclusion, this is the first preliminary report of the presence of H1 in human tears. H1 concentrations are lower in ADDE patients and H1 may have diagnostic potential in evaluation ADDE patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofissue1
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume9
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.titlePresence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKalmodia, S; Son, KN; Cao, D; Lee, BS; Surenkhuu, B; Shah, D; Ali, M; Balasubramaniam, A; Jain, S; Aakalu, VK, Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study, Scientific Reports, 2019, 9 (1)
dcterms.dateAccepted2019-07-02
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-04-22T22:49:47Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorShah, Dhara


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