Efficacy of GBT440 to Left-Shift the Oxy-Hemoglobin Dissociation Curve in Healthy Individuals and Preserve Arterial Saturation During Submaximal Hypoxic Exercise

Stewart, G; Cross, T; Chase, S; Joyner, M; Curry, T; Isautier, J; Lehrer, J; Vlahakis, NE; Johnson, BD

Author(s)

Stewart, G

Cross, T

Chase, S

Joyner, M

Curry, T

Isautier, J

Lehrer, J

Vlahakis, NE

Johnson, BD

Griffith University Author(s)

Stewart, Glenn

Year published

2018

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Abstract

Introduction: Numerous conditions can cause hypoxia-induced cardiopulmonary perturbations that are associated with the degree of arterial oxygen desaturation. Global Blood Therapeutics (GBT) has developed an allosteric modulator of hemoglobin (GBT440) that increases the affinity of hemoglobin for oxygen and left shifts the oxy-hemoglobin dissociation curve. Accordingly, this study investigated the efficacy of GBT440 to preserve arterial oxygen saturation while exercising during acute hypoxia.Introduction: Numerous conditions can cause hypoxia-induced cardiopulmonary perturbations that are associated with the degree of arterial oxygen desaturation. Global Blood Therapeutics (GBT) has developed an allosteric modulator of hemoglobin (GBT440) that increases the affinity of hemoglobin for oxygen and left shifts the oxy-hemoglobin dissociation curve. Accordingly, this study investigated the efficacy of GBT440 to preserve arterial oxygen saturation while exercising during acute hypoxia.
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