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dc.contributor.authorLi, HT
dc.contributor.authorWu, XD
dc.contributor.authorDavey, AK
dc.contributor.authorWang, J
dc.date.accessioned2017-05-03T16:01:05Z
dc.date.available2017-05-03T16:01:05Z
dc.date.issued2011
dc.date.modified2011-07-01T06:57:43Z
dc.identifier.issn0951-418X
dc.identifier.doi10.1002/ptr.3238
dc.identifier.urihttp://hdl.handle.net/10072/39342
dc.description.abstractThe aim of the study was to investigate the effects of baicalin on blood glucose, insulin and cytokine levels. Rat diabetes was induced by intraperitoneal (i.p.) injection of nicotinamide and streptozotocin. Diabetic rats were dosed with i.p. baicalin or oral metformin daily for 8 days. Blood glucose, insulin and hepatic glycogen were determined using conventional methods. The activity of hepatic hexokinase was determined using a coupled assay with glucose-6-phosphate dehydrogenase. Serum levels of interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and adiponectin were measured by enzyme-linked immunosorbent assay. Administration of baicalin at 50 or 100 mg/kg signifi cantly decreased plasma glucose levels in a dose dependent manner. The serum insulin level was not increased by baicalin treatment. Administration of baicalin at a high dose (100 mg/kg) resulted in a signifi cant increase of liver glycogen content and a reduction of serum TNF-a. The activity of hepatic hexokinase was signifi cantly increased after dosing baicalin at 25, 50 or 10 mg/kg. Administration of baicalin (50 or 10 mg/kg) or metformin (10 mg/kg) signifi cantly alleviated the morphological injury to the pancreas caused by STZ. The possible mechanisms contributing to the hypoglycemic effect include increasing the hepatic glycogen content and glycolysis, and reducing the serum levels of TNF-a.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom189
dc.relation.ispartofpageto194
dc.relation.ispartofissue2
dc.relation.ispartofjournalPhytotherapy Research
dc.relation.ispartofvolume25
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode321499
dc.titleAntihyperglycemic Effects of Baicalin on Streptozotocin – Nicotinamide induced Diabetic Rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorDavey, Andrew


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