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dc.contributor.authorChan, RJ
dc.contributor.authorCooper, B
dc.contributor.authorKoczwara, B
dc.contributor.authorChan, A
dc.contributor.authorTan, CJ
dc.contributor.authorPaul, SM
dc.contributor.authorDunn, LB
dc.contributor.authorConley, YP
dc.contributor.authorKober, KM
dc.contributor.authorLevine, JD
dc.contributor.authorMiaskowski, C
dc.date.accessioned2021-05-20T00:06:41Z
dc.date.available2021-05-20T00:06:41Z
dc.date.issued2020
dc.identifier.issn0941-4355en_US
dc.identifier.doi10.1007/s00520-020-05312-4en_US
dc.identifier.urihttp://hdl.handle.net/10072/393492
dc.description.abstractPurpose: A breast cancer diagnosis has a substantial economic impact. Study aims were to evaluate for inter-individual differences in cancer’s level of interference with employment and identify phenotypic and symptom characteristics associated with higher levels of interference. Methods: Patients (n = 387) were enrolled prior to breast cancer surgery and followed for 12 months. Interference with employment was measured using a 0 (no problem) to 10 (severe problem) numeric rating scale. Hierarchical linear modeling (HLM) was used to evaluate for inter-individual differences in trajectories of employment interference and characteristics associated with employment interference at enrollment and over 12 months. Results: Patients’ mean age was 55.0 (±11.7) years and the majority underwent breast conservation surgery (80.6%). Mean employment interference score was 3.2 (±3.7). Unconditional model for employment interference demonstrated a decreasing linear trend (−.076/month). Younger age, lower income, higher pain intensity, and having an axillary lymph node dissection were associated with higher pre-surgical interference scores. Having a sentinel lymph node biopsy was associated with ongoing employment interference scores. Higher sleep disturbance scores were associated with both initial and ongoing employment interference scores. Receipt of chemotherapy, use of complementary or alternative therapies, and re-excision or mastectomy following surgery were significant time varying covariates. Conclusion: This study is the first to use HLM to describe inter-individual differences in the trajectories of cancer’s interference with employment and associated factors prior to and for 12 months following breast cancer surgery. Patients with the identified risk factors warrant ongoing assessments of employment interference and appropriate referrals.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLCen_US
dc.relation.ispartofpagefrom4677en_US
dc.relation.ispartofpageto4686en_US
dc.relation.ispartofjournalSupportive Care in Canceren_US
dc.relation.ispartofvolume28en_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchPsychology and Cognitive Sciencesen_US
dc.subject.fieldofresearchcode11en_US
dc.subject.fieldofresearchcode17en_US
dc.subject.keywordsBreast canceren_US
dc.subject.keywordsEmploymenten_US
dc.subject.keywordsFinancial toxicityen_US
dc.subject.keywordsHierarchical linear modelingen_US
dc.subject.keywordsInterferenceen_US
dc.titleA longitudinal analysis of phenotypic and symptom characteristics associated with inter-individual variability in employment interference in patients with breast canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationChan, RJ; Cooper, B; Koczwara, B; Chan, A; Tan, CJ; Paul, SM; Dunn, LB; Conley, YP; Kober, KM; Levine, JD; Miaskowski, C, A longitudinal analysis of phenotypic and symptom characteristics associated with inter-individual variability in employment interference in patients with breast cancer, Supportive Care in Cancer, 2020, 28, pp. 4677–4686en_US
dcterms.dateAccepted2020-01-14
dc.date.updated2020-04-29T05:03:49Z
dc.description.versionAccepted Manuscript (AM)en_US
gro.rights.copyright© 2020 Springer Berlin/Heidelberg. This is an electronic version of an article published in Supportive Care in Cancer, VOLUMEISSUEPAGESYEAR. Supportive Care in Cancer is available online at: http://link.springer.com/ with the open URL of your article.en_US
gro.hasfulltextFull Text
gro.griffith.authorChan, Ray


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