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  • Management of patients with hepatocellular adenoma: a single-institution experience

    Author(s)
    Nahm, Christopher B
    Parker, Nicholas
    Gundara, Justin S
    Gill, Anthony J
    Bhimani, Nazim
    Samra, Jaswinder S
    Hugh, Thomas J
    Griffith University Author(s)
    Gundara, Justin
    Year published
    2020
    Metadata
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    Abstract
    Background: Hepatocellular adenoma (HCA) is a rare benign liver tumour that may cause diagnostic and management dilemmas. This study describes the clinical and histopathological characteristics of patients who were treated for HCA in a tertiary referral hospital over a 17-year period. Methods: A retrospective review was performed of prospectively collected data of all patients treated for HCA within the Northern Upper GI Surgical unit between 2002 and 2018. Immunohistochemical β-catenin expression was evaluated. Results: Thirty-two patients had histological or radiologically confirmed HCA. Twenty-eight patients underwent 30 ...
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    Background: Hepatocellular adenoma (HCA) is a rare benign liver tumour that may cause diagnostic and management dilemmas. This study describes the clinical and histopathological characteristics of patients who were treated for HCA in a tertiary referral hospital over a 17-year period. Methods: A retrospective review was performed of prospectively collected data of all patients treated for HCA within the Northern Upper GI Surgical unit between 2002 and 2018. Immunohistochemical β-catenin expression was evaluated. Results: Thirty-two patients had histological or radiologically confirmed HCA. Twenty-eight patients underwent 30 operations and four patients were treated conservatively. The median age of the operative group was 43 years (range 19–83) and most patients were female (95%). The median body mass index was 28.7 (range 20–51), and nine patients (33%) were obese. Seven patients (25%) had multifocal HCA. Evidence of prior bleed or rupture or a perceived risk of either a bleed or malignant change (i.e. tumours ≥50 mm) were the most common indications for resection. There were no perioperative mortalities. Nuclear expression of β-catenin by immunohistochemical staining was negative in all cases and there was no malignancy identified in any of the resected lesions. Two patients required transarterial embolization and two patients required a second liver resection for residual HCA. Conclusion: HCA is a rare lesion predominantly affecting females. Haemorrhage is seen frequently on imaging studies, occasionally requiring urgent angioembolization and/or surgical intervention. Malignant transformation and immunohistochemical β-catenin expression are uncommon. HCA may be multifocal and residual tumours usually require ongoing surveillance and occasionally further intervention.
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    Journal Title
    ANZ Journal of Surgery
    DOI
    https://doi.org/10.1111/ans.15648
    Note
    This publication was entered as an advanced online version.
    Subject
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Surgery
    hepatocellular adenoma
    retrospective review
    Publication URI
    http://hdl.handle.net/10072/393568
    Collection
    • Journal articles

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