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dc.contributor.authorVarcin, Kandice J
dc.contributor.authorNelson, Charles A
dc.date.accessioned2020-05-05T03:32:08Z
dc.date.available2020-05-05T03:32:08Z
dc.date.issued2016
dc.identifier.issn1350-7540
dc.identifier.doi10.1097/wco.0000000000000298
dc.identifier.urihttp://hdl.handle.net/10072/393586
dc.description.abstractPurpose of review—The delineation of biomarkers in autism spectrum disorder (ASD) offers a promising approach to inform precision-medicine based approaches to ASD diagnosis and treatment and to move toward a mechanistic description of the disorder. However, biomarkers with sufficient sensitivity or specificity for clinical application in ASD are yet to be realized. Here, we review recent evidence for early, low-level alterations in brain and behavior development that may offer promising avenues for biomarker development in ASD. Recent findings—Accumulating evidence suggests that signs associated with ASD may unfold in a manner that maps onto the hierarchical organization of brain development. Genetic and neuroimaging evidence points towards perturbations in brain development early in life, and emerging evidence indicates that sensorimotor development may be amongst the earliest emerging signs associated with ASD, preceding social and cognitive impairment. Summary—The search for biomarkers of risk, prediction and stratification in ASD may be advanced through a developmental neuroscience approach that looks outside of the core signs of ASD and considers the bottom-up nature of brain development alongside the dynamic nature of development over time. We provide examples of assays that could be incorporated in studies to target low-level circuits.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWolters Kluwer Health
dc.relation.ispartofpagefrom123
dc.relation.ispartofpageto129
dc.relation.ispartofissue2
dc.relation.ispartofjournalCurrent Opinion in Neurology
dc.relation.ispartofvolume29
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.titleA developmental neuroscience approach to the search for biomarkers in autism spectrum disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationVarcin, KJ; Nelson, CA, A developmental neuroscience approach to the search for biomarkers in autism spectrum disorder, Current Opinion in Neurology, 2016, 29 (2), pp. 123-129
dc.date.updated2020-05-05T02:11:08Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2016 LWW. This is a non-final version of an article published in final form in Current Opinion in Neurology 29(2): 123–129, 2016. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.
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gro.griffith.authorVarcin, Kandice J.


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