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dc.contributor.authorChoudhary, Preeti
dc.contributor.authorStrugnell, Wendy
dc.contributor.authorPuranik, Rajesh
dc.contributor.authorHamilton-Craig, Christian
dc.contributor.authorKutty, Shelby
dc.contributor.authorCelermajer, David S
dc.date.accessioned2020-05-05T03:51:41Z
dc.date.available2020-05-05T03:51:41Z
dc.date.issued2020
dc.identifier.issn1047-9511
dc.identifier.doi10.1017/S1047951119001872
dc.identifier.urihttp://hdl.handle.net/10072/393589
dc.description.abstractObjective:Left ventricular non-compaction is an architectural abnormality of the myocardium, associated with heart failure, systemic thromboembolism, and arrhythmia. We sought to assess the prevalence of left ventricular non-compaction in patients with single ventricle heart disease and its effects on ventricular function. Methods:Cardiac MRI of 93 patients with single ventricle heart disease (mean age 24 ± 8 years; 55% male) from three tertiary congenital centres was retrospectively reviewed; 65 of these had left ventricular morphology and are the subject of this report. The presence of left ventricular non-compaction was defined as having a non-compacted:compacted (NC:C) myocardial thickness ratio >2.3:1. The distribution of left ventricular non-compaction, ventricular volumes, and function was correlated with clinical data. Results:The prevalence of left ventricular non-compaction was 37% (24 of 65 patients) with a mean of 4 ± 2 affected segments. The distribution was apical in 100%, mid-ventricular in 29%, and basal in 17% of patients. Patients with left ventricular non-compaction had significantly higher end-diastolic (128 ± 44 versus 104 ± 46 mL/m2, p = 0.047) and end-systolic left ventricular volumes (74 ± 35 versus 56 ± 35 mL/m2, p = 0.039) with lower left ventricular ejection fraction (44 ± 11 versus 50 ± 9%, p = 0.039) compared to those with normal compaction. The number of segments involved did not correlate with ventricular function (p = 0.71). Conclusions:Left ventricular non-compaction is frequently observed in patients with left ventricle-type univentricular hearts, with predominantly apical and mid-ventricular involvement. The presence of non-compaction is associated with increased indexed end-diastolic volumes and impaired systolic function.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCambridge University Press (CUP)
dc.relation.ispartofpagefrom12
dc.relation.ispartofpageto18
dc.relation.ispartofissue1
dc.relation.ispartofjournalCardiology in the Young
dc.relation.ispartofvolume30
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.subject.keywordsFontan
dc.subject.keywordsadult congenital heart disease
dc.subject.keywordscardiac MRI
dc.subject.keywordsheart failure
dc.subject.keywordsnon-compaction
dc.titleLeft ventricular non-compaction in patients with single ventricle heart disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChoudhary, P; Strugnell, W; Puranik, R; Hamilton-Craig, C; Kutty, S; Celermajer, DS, Left ventricular non-compaction in patients with single ventricle heart disease, Cardiology in the Young, 2019, 30 (1), pp. 12-18
dc.date.updated2020-05-05T03:49:20Z
gro.hasfulltextNo Full Text
gro.griffith.authorStrugnell, Wendy
gro.griffith.authorHamilton-Craig, Christian


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