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dc.contributor.authorChoudhary, Preeti
dc.contributor.authorStrugnell, Wendy
dc.contributor.authorPuranik, Rajesh
dc.contributor.authorHamilton-Craig, Christian
dc.contributor.authorKutty, Shelby
dc.contributor.authorCelermajer, David S
dc.description.abstractObjective:Left ventricular non-compaction is an architectural abnormality of the myocardium, associated with heart failure, systemic thromboembolism, and arrhythmia. We sought to assess the prevalence of left ventricular non-compaction in patients with single ventricle heart disease and its effects on ventricular function. Methods:Cardiac MRI of 93 patients with single ventricle heart disease (mean age 24 ± 8 years; 55% male) from three tertiary congenital centres was retrospectively reviewed; 65 of these had left ventricular morphology and are the subject of this report. The presence of left ventricular non-compaction was defined as having a non-compacted:compacted (NC:C) myocardial thickness ratio >2.3:1. The distribution of left ventricular non-compaction, ventricular volumes, and function was correlated with clinical data. Results:The prevalence of left ventricular non-compaction was 37% (24 of 65 patients) with a mean of 4 ± 2 affected segments. The distribution was apical in 100%, mid-ventricular in 29%, and basal in 17% of patients. Patients with left ventricular non-compaction had significantly higher end-diastolic (128 ± 44 versus 104 ± 46 mL/m2, p = 0.047) and end-systolic left ventricular volumes (74 ± 35 versus 56 ± 35 mL/m2, p = 0.039) with lower left ventricular ejection fraction (44 ± 11 versus 50 ± 9%, p = 0.039) compared to those with normal compaction. The number of segments involved did not correlate with ventricular function (p = 0.71). Conclusions:Left ventricular non-compaction is frequently observed in patients with left ventricle-type univentricular hearts, with predominantly apical and mid-ventricular involvement. The presence of non-compaction is associated with increased indexed end-diastolic volumes and impaired systolic function.
dc.publisherCambridge University Press (CUP)
dc.relation.ispartofjournalCardiology in the Young
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.keywordsadult congenital heart disease
dc.subject.keywordscardiac MRI
dc.subject.keywordsheart failure
dc.titleLeft ventricular non-compaction in patients with single ventricle heart disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChoudhary, P; Strugnell, W; Puranik, R; Hamilton-Craig, C; Kutty, S; Celermajer, DS, Left ventricular non-compaction in patients with single ventricle heart disease, Cardiology in the Young, 2019, 30 (1), pp. 12-18
gro.hasfulltextNo Full Text
gro.griffith.authorStrugnell, Wendy
gro.griffith.authorHamilton-Craig, Christian

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