dc.contributor.author | Palamuthusingam, Dharmenaan | |
dc.contributor.author | Mantha, Murty | |
dc.contributor.author | Oliver, Kimberley | |
dc.contributor.author | Bavishi, Ketan | |
dc.contributor.author | Dheda, Shyam | |
dc.date.accessioned | 2020-05-06T03:36:52Z | |
dc.date.available | 2020-05-06T03:36:52Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1320-5358 | |
dc.identifier.doi | 10.1111/nep.12925 | |
dc.identifier.uri | http://hdl.handle.net/10072/393622 | |
dc.description.abstract | Kidney involvement is an under-recognized complication of non-Hodgkin lymphomas. They occur in a variety of mechanisms and differ widely in their clinical presentation. We take this opportunity to report a case of a 65 year-old man who developed a rapidly progressive glomerulonephritis within days after completing his first cycle of R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) chemotherapy for newly diagnosed mantle cell lymphoma. He was odematous, hypertensive, oliguric with nephrotic range proteinuria and an active urine sediment. A renal biopsy showed a crescentic C3 glomerulonephritis (C3GN) with no evidence endocapillary or mesangial hypercellularity. He was promptly treated with immunosuppression and dialysis, with resumption of his chemotherapy. Genetic testing on complement proteins revealed a homozygous deletion spanning the CFHR1 and CFHR3 genes. Crescentic C3GN is a rare form of kidney injury, and this is the first known case of lymphoma-associated kidney involvement manifesting as C3GN. This article explores the possible mechanism of disease and reviews the literature of lymphoma-related kidney disease. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofpagefrom | 261 | |
dc.relation.ispartofpageto | 264 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Nephrology | |
dc.relation.ispartofvolume | 22 | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Urology & Nephrology | |
dc.subject.keywords | acute kidney injury | |
dc.subject.keywords | glomerulonephritis | |
dc.title | Mini review: A unique case of crescentic C3 glomerulonephritis | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Palamuthusingam, D; Mantha, M; Oliver, K; Bavishi, K; Dheda, S, Mini review: A unique case of crescentic C3 glomerulonephritis, Nephrology, 2017, 22 (3), pp. 261-264 | |
dcterms.dateAccepted | 2016-09-12 | |
dc.date.updated | 2020-05-06T02:34:39Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Palamuthusingam, Dharmenaan | |