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dc.contributor.authorPalamuthusingam, Dharmenaan
dc.contributor.authorMantha, Murty
dc.contributor.authorOliver, Kimberley
dc.contributor.authorBavishi, Ketan
dc.contributor.authorDheda, Shyam
dc.date.accessioned2020-05-06T03:36:52Z
dc.date.available2020-05-06T03:36:52Z
dc.date.issued2017
dc.identifier.issn1320-5358
dc.identifier.doi10.1111/nep.12925
dc.identifier.urihttp://hdl.handle.net/10072/393622
dc.description.abstractKidney involvement is an under-recognized complication of non-Hodgkin lymphomas. They occur in a variety of mechanisms and differ widely in their clinical presentation. We take this opportunity to report a case of a 65 year-old man who developed a rapidly progressive glomerulonephritis within days after completing his first cycle of R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) chemotherapy for newly diagnosed mantle cell lymphoma. He was odematous, hypertensive, oliguric with nephrotic range proteinuria and an active urine sediment. A renal biopsy showed a crescentic C3 glomerulonephritis (C3GN) with no evidence endocapillary or mesangial hypercellularity. He was promptly treated with immunosuppression and dialysis, with resumption of his chemotherapy. Genetic testing on complement proteins revealed a homozygous deletion spanning the CFHR1 and CFHR3 genes. Crescentic C3GN is a rare form of kidney injury, and this is the first known case of lymphoma-associated kidney involvement manifesting as C3GN. This article explores the possible mechanism of disease and reviews the literature of lymphoma-related kidney disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom261
dc.relation.ispartofpageto264
dc.relation.ispartofissue3
dc.relation.ispartofjournalNephrology
dc.relation.ispartofvolume22
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsUrology & Nephrology
dc.subject.keywordsacute kidney injury
dc.subject.keywordsglomerulonephritis
dc.titleMini review: A unique case of crescentic C3 glomerulonephritis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPalamuthusingam, D; Mantha, M; Oliver, K; Bavishi, K; Dheda, S, Mini review: A unique case of crescentic C3 glomerulonephritis, Nephrology, 2017, 22 (3), pp. 261-264
dcterms.dateAccepted2016-09-12
dc.date.updated2020-05-06T02:34:39Z
gro.hasfulltextNo Full Text
gro.griffith.authorPalamuthusingam, Dharmenaan


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