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dc.contributor.authorThambar, S
dc.contributor.authorKulkarni, S
dc.contributor.authorArmstrong, S
dc.contributor.authorNikolarakos, D
dc.date.accessioned2020-05-07T03:53:45Z
dc.date.available2020-05-07T03:53:45Z
dc.date.issued2020
dc.identifier.issn0266-4356
dc.identifier.doi10.1016/j.bjoms.2020.02.007
dc.identifier.urihttp://hdl.handle.net/10072/393673
dc.description.abstractThe aim of this review was to critically investigate and assess the evidence relating to the use and efficacy of botulinum toxin (BTX) in the management of temporomandibular joint disorders (TMD) and masticatory myofascial pain. A comprehensive search was conducted of PubMed, Scopus, Embase, and Cochrane CENTRAL, to find relevant studies from the last 30 years up to the end of July 2018. Seven were identified. Three showed a significant reduction in pain between the BTX and placebo groups and one showed a clinical, but not a significant, difference. In one that compared BTX with another novel treatment, myofascial pain reduced equally in both groups, and in the remaining two there was no significant difference in pain reduction between the BTX and control groups. Of the four studies that assessed mouth opening, two reported that BTX had resulted in a slight improvement; one reported no improvement, and the other a worsening of the condition. A meta-analysis was not possible because of the considerable variation in the studies’ designs, the heterogeneity between the groups, and the different assessment tools used. Despite showing benefits, consensus on the therapeutic benefit of BTX in the management of myofascial TMD is lacking. Further randomised controlled trials with larger sample sizes, minimal bias, and longer follow-up periods are now needed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom508
dc.relation.ispartofpageto519
dc.relation.ispartofissue5
dc.relation.ispartofjournalBritish Journal of Oral and Maxillofacial Surgery
dc.relation.ispartofvolume58
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode1105
dc.subject.keywordsBotulinum Toxin
dc.subject.keywordsMyofacial Masticatory Muscle Pain
dc.subject.keywordsTemporomandibular Joint Disorders
dc.titleBotulinum toxin in the management of temporomandibular disorders: a systematic review
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationThambar, S; Kulkarni, S; Armstrong, S; Nikolarakos, D, Botulinum toxin in the management of temporomandibular disorders: a systematic review, British Journal of Oral and Maxillofacial Surgery, 2020
dcterms.dateAccepted2020-02-10
dc.date.updated2020-05-07T03:40:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorThambar, Samuel V.
gro.griffith.authorKulkarni, Sachin


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