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dc.contributor.authorKasem, K
dc.contributor.authorLam, AK
dc.date.accessioned2020-05-08T01:45:12Z
dc.date.available2020-05-08T01:45:12Z
dc.date.issued2020
dc.identifier.issn1064-3745
dc.identifier.doi10.1007/978-1-0716-0377-2_21
dc.identifier.urihttp://hdl.handle.net/10072/393693
dc.description.abstractImmunohistochemistry is the identification of a cell protein by a specific antibody targeting that protein. It is the most common ancillary test to study the pathology of cancer. Immunohistochemical protein markers are used to differentiate poorly differentiated squamous cell carcinoma from poorly differentiated adenocarcinoma or neuroendocrine carcinomas. They could be used to identify and type the carcinoma in metastatic locations. Importantly, immunodetection of markers also helps in prediction of response to therapies as well as assessing the different biomarkers related to the pathogenesis and clinical behavior of esophageal squamous cell carcinoma. Successful application of the immunochemistry depends on understanding the mechanisms and principles as well as the limitations of the procedure. Automation of the procedure by different models of automatic stainers is widely used in diagnostic laboratories. The use of autostainers streamlines the workflows and certainly reduces the labor, time, and cost of using immunohistochemistry in clinical and research settings.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer US
dc.relation.ispartofpagefrom279
dc.relation.ispartofpageto294
dc.relation.ispartofjournalMethods in Molecular Biology
dc.relation.ispartofvolume2129
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.subject.keywordsAutostainer
dc.subject.keywordsEsophagus
dc.subject.keywordsImmunohistochemical
dc.subject.keywordsImmunohistochemistry
dc.subject.keywordsSquamous cell carcinoma
dc.titleImmunohistochemistry for Protein Detection in Esophageal Squamous Cell Carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKasem, K; Lam, AK, Immunohistochemistry for Protein Detection in Esophageal Squamous Cell Carcinoma, Methods in Molecular Biology, 2020, 2129, pp. 279-294
dc.date.updated2020-05-08T01:44:18Z
gro.hasfulltextNo Full Text
gro.griffith.authorLam, Alfred K.


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