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dc.contributor.authorIslam, F
dc.contributor.authorGopalan, V
dc.contributor.authorLam, AK
dc.date.accessioned2020-05-08T02:04:37Z
dc.date.available2020-05-08T02:04:37Z
dc.date.issued2020
dc.identifier.issn1064-3745
dc.identifier.doi10.1007/978-1-0716-0377-2_18
dc.identifier.urihttp://hdl.handle.net/10072/393703
dc.description.abstractMicroRNAs (miRNAs) are 20–22 nucleotides long single-stranded noncoding RNAs. They regulate gene expression posttranscriptionally by base pairing with the complementary sequences in the 3′-untranslated region of their targeted mRNA. Aberrant expression of miRNAs leads to alterations in the expression of oncogenes and tumor suppressors, thereby affecting cellular growth, proliferation, apoptosis, motility, and invasion capacity of gastrointestinal cells, including cells of esophageal squamous cell carcinoma (ESCC). Thus, alterations in miRNAs expression associated with the pathogenesis and progression of ESCC. In addition, expression profiles of miRNAs correlated with various clinicopathological factors, including pathological stages, histological differentiation, invasion, metastasis of cancer, as well as survival rates and therapy response of patients with ESCC. Consequently, expression profiles of miRNAs could be useful as diagnostic, prognostic, and prediction biomarkers in ESCC. Herein, we describe the quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and microarray methods for detection and quantitate miRNAs in ESCC. In addition, we summarize the roles of miRNAs in ESCC pathogenesis, progression, and prognosis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer US
dc.relation.ispartofpagefrom241
dc.relation.ispartofpageto257
dc.relation.ispartofjournalMethods in Molecular Biology
dc.relation.ispartofvolume2129
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3404
dc.subject.keywordsCancer pathogenesis
dc.subject.keywordsMicroRNAs
dc.subject.keywordsMicroarray
dc.subject.keywordsPrognosis
dc.subject.keywordsqRT-PCR
dc.titleRoles of MicroRNAs in Esophageal Squamous Cell Carcinoma Pathogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationIslam, F; Gopalan, V; Lam, AK, Roles of MicroRNAs in Esophageal Squamous Cell Carcinoma Pathogenesis, Methods in Molecular Biology, 2020, 2129, pp. 241-257
dc.date.updated2020-05-08T02:03:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorGopalan, Vinod
gro.griffith.authorLam, Alfred K.
gro.griffith.authorIslam, Farhad


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