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dc.contributor.authorBoukalova, Stepana
dc.contributor.authorHubackova, Sona
dc.contributor.authorMilosevic, Mirko
dc.contributor.authorEzrova, Zuzana
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorRohlena, Jakub
dc.date.accessioned2020-05-08T02:50:38Z
dc.date.available2020-05-08T02:50:38Z
dc.date.issued2020
dc.identifier.issn0925-4439
dc.identifier.doi10.1016/j.bbadis.2020.165759
dc.identifier.urihttp://hdl.handle.net/10072/393712
dc.description.abstractDihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofissue6
dc.relation.ispartofjournalBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.relation.ispartofvolume1866
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biochemistry and Metabolomics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1101
dc.subject.fieldofresearchcode1103
dc.subject.keywordsBioenergetics
dc.subject.keywordsCancer
dc.subject.keywordsDe novo pyrimidine synthesis
dc.subject.keywordsDehydroorotate dehydrogenase
dc.subject.keywordsOxidative phosphorylation
dc.titleDihydroorotate dehydrogenase in oxidative phosphorylation and cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBoukalova, S; Hubackova, S; Milosevic, M; Ezrova, Z; Neuzil, J; Rohlena, J, Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020, 1866 (6)
dcterms.dateAccepted2020-03-04
dc.date.updated2020-05-07T05:15:48Z
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri


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