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  • Plasticity of Cancer Stem Cell: Origin and Role in Disease Progression and Therapy Resistance

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    Pillai347085-Accepted.pdf (1.742Mb)
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    Author(s)
    Das, Plabon Kumar
    Pillai, Suja
    Rakib, Md Abdur
    Khanam, Jahan Ara
    Gopalan, Vinod
    Lam, Alfred KY
    Islam, Farhadul
    Griffith University Author(s)
    Lam, Alfred K.
    Gopalan, Vinod
    Islam, Farhad
    Year published
    2020
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    Abstract
    In embryonic development and throughout life, there are some cells can exhibit phenotypic plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In normal development, plasticity is highly regulated whereas cancer cells re-activate this dynamic ability for their own progression. The re-activation of these mechanisms enables cancer cells to acquire a cancer stem cell (CSC) phenotype- a subpopulation of cells with increased ability to survive in a hostile environment and resist therapeutic insults. There are several contributors fuel CSC plasticity in different stages of disease ...
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    In embryonic development and throughout life, there are some cells can exhibit phenotypic plasticity. Phenotypic plasticity is the ability of cells to differentiate into multiple lineages. In normal development, plasticity is highly regulated whereas cancer cells re-activate this dynamic ability for their own progression. The re-activation of these mechanisms enables cancer cells to acquire a cancer stem cell (CSC) phenotype- a subpopulation of cells with increased ability to survive in a hostile environment and resist therapeutic insults. There are several contributors fuel CSC plasticity in different stages of disease progression such as a complex network of tumour stroma, epidermal microenvironment and different sub-compartments within tumour. These factors play a key role in the transformation of tumour cells from a stable condition to a progressive state. In addition, flexibility in the metabolic state of CSCs helps in disease progression. Moreover, epigenetic changes such as chromatin, DNA methylation could stimulate the phenotypic change of CSCs. Development of resistance to therapy due to highly plastic behaviour of CSCs is a major cause of treatment failure in cancers. However, recent studies explored that plasticity can also expose the weaknesses in CSCs, thereby could be utilized for future therapeutic development. Therefore, in this review, we discuss how cancer cells acquire the plasticity, especially the role of the normal developmental process, tumour microenvironment, and epigenetic changes in the development of plasticity. We further highlight the therapeutic resistance property of CSCs attributed by plasticity. Also, outline some potential therapeutic options against plasticity of CSCs.
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    Journal Title
    Stem Cell Reviews and Reports
    Volume
    16
    Issue
    2
    DOI
    https://doi.org/10.1007/s12015-019-09942-y
    Copyright Statement
    © Springer Science+Business Media, LLC, part of Springer Nature 2020. This is an electronic version of an article published in Stem Cell Reviews and Reports, 2020, 16 (2), pp. 397-412. Stem Cell Reviews and Reports is available online at: http://link.springer.com/ with the open URL of your article.
    Subject
    Biomedical and clinical sciences
    Biological sciences
    Science & Technology
    Life Sciences & Biomedicine
    Cell & Tissue Engineering
    Cell Biology
    Medicine, Research & Experimental
    Publication URI
    http://hdl.handle.net/10072/393722
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    • Journal articles

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