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dc.contributor.authorJung, Richard G
dc.contributor.authorParlow, Simon
dc.contributor.authorSimard, Trevor
dc.contributor.authorChen, Christopher
dc.contributor.authorGhataura, Harshpreet
dc.contributor.authorKishore, Aditya
dc.contributor.authorPerera, Aravinda
dc.contributor.authorMoreland, Rob
dc.contributor.authorHughes, Ian
dc.contributor.authorTavella, Rosanna
dc.contributor.authorHibbert, Benjamin
dc.contributor.authorBeltrame, John
dc.contributor.authorSingh, Kuljit
dc.date.accessioned2020-05-11T02:35:51Z
dc.date.available2020-05-11T02:35:51Z
dc.date.issued2020
dc.identifier.issn1473-5830
dc.identifier.doi10.1097/MCA.0000000000000903
dc.identifier.urihttp://hdl.handle.net/10072/393747
dc.description.abstractINTRODUCTION: Clinical characteristics and outcomes of patients diagnosed with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCA) remain largely unknown. Furthermore, we do not yet understand if women with MINOCA have worse outcomes similar to what has historically been observed with MI. The aims of the current study were to evaluate the (1) incidence of MINOCA in patients presenting with MI, (2) compare in-hospital outcomes of MINOCA and obstructive atherosclerotic coronary artery disease MI (OACD-MI), and (3) comparison of in-hospital clinical outcomes of patients with MINOCA stratified by sex. METHODS AND RESULTS: In this observational study, we combined data from two large university hospitals from Canada and Australia. Clinical characteristics and in-hospital outcomes of MINOCA and OACD-MI were analyzed by matching these patients in a 1:1 ratio after selecting patients with OACD-MI by systematic random sampling. Clinical characteristics associated with MINOCA were identified through multivariate logistic regression. Primary outcome of interest was net adverse cardiovascular events (NACE) defined as death, heart failure, stroke, and major bleeding. The incidence rate of MINOCA was 9.5%. Women, absence of traditional cardiac risk factors, and absence of ST-deviations on ECG were associated with diagnosis of MINOCA on angiography. NACE (P = 0.0001), death (P = 0.019), stroke (P = 0.002), and heart failure (P = 0.001) were significantly lower in patients with MINOCA. Subgroup analysis of women and men diagnosed with MINOCA revealed similar in-hospital outcomes. CONCLUSION: The incidence of MINOCA was 9.5%. Compared to OACD-MI, patients with MINOCA have less cardiac risk factors. In-hospital outcomes of patients diagnosed with MINOCA were better than OACD-MI.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofjournalCoronary Artery Disease
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3202
dc.titleClinical features, sex differences and outcomes of myocardial infarction with nonobstructive coronary arteries: a registry analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationJung, RG; Parlow, S; Simard, T; Chen, C; Ghataura, H; Kishore, A; Perera, A; Moreland, R; Hughes, I; Tavella, R; Hibbert, B; Beltrame, J; Singh, K, Clinical features, sex differences and outcomes of myocardial infarction with nonobstructive coronary arteries: a registry analysis, Coronary Artery Disease, 2020
dc.date.updated2020-05-11T00:46:57Z
gro.description.notepublicThis publication was entered as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorSingh, Kuljit


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