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dc.contributor.authorCox, Emily R
dc.contributor.authorGajanand, Trishan
dc.contributor.authorBurton, Nicola W
dc.contributor.authorCoombes, Jeff S
dc.contributor.authorCoombes, Brooke K
dc.date.accessioned2020-05-12T00:28:11Z
dc.date.available2020-05-12T00:28:11Z
dc.date.issued2020
dc.identifier.issn0168-8227
dc.identifier.doi10.1016/j.diabres.2020.108168
dc.identifier.urihttp://hdl.handle.net/10072/393763
dc.description.abstractAIMS: People with type 2 diabetes (T2D) have a greater prevalence of musculoskeletal and neuropathic pain. This exploratory analysis investigated whether exercise of different intensities leads to changes in self-reported musculoskeletal pain or symptoms of diabetic neuropathy in inactive individuals with type 2 diabetes. METHODS: Thirty-two inactive adults with T2D (59% male, mean age 58.7±9.1yrs, median HbA1c 7.8%) were randomised to usual care (CON), supervised combined aerobic and resistance moderate-intensity continuous training (C-MICT), or supervised combined high-intensity interval training (C-HIIT). At baseline and 8-weeks, musculoskeletal and neuropathic pain were evaluated using a modified Nordic Musculoskeletal Questionnaire and the Neuropathy Total Symptom Score-6 respectively. Quantitative sensory testing was used to determine thermal, mechanical and vibration detection thresholds, as well as pain pressure thresholds. Adverse events were recorded throughout the intervention. RESULTS: Compared to CON, reduction in musculoskeletal pain intensity was significantly greater for C-HIIT (MD -5.4, 95% CI [-10.6 to -0.2], p=0.04) and non-significantly greater for C-MICT (MD -5.9 [-12.4 to 0.7], p=0.08). Changes in neuropathy symptoms were not different between C-HIIT and CON (MD 1.0 [-0.9 to 2.8], p=0.31), or C-MICT and CON (MD 0.2 [-3.1 to 3.6], p=0.89). No differences in sensory function were observed between groups. Similar rates of adverse events were seen in both exercise interventions (19 C-HIIT; 17 C-MICT), all but one of which were mild. CONCLUSIONS: Preliminary data suggests 8-weeks of high-intensity combined aerobic and resistance exercise may be safely prescribed for inactive individuals with T2D and may reduce musculoskeletal pain but not neuropathic symptoms.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofjournalDiabetes Research and Clinical Practice
dc.relation.ispartofvolume164
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchClinical and health psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5203
dc.subject.keywordsDiabetic peripheral neuropathy
dc.subject.keywordshigh-intensity interval training
dc.subject.keywordsmoderate intensity continuous training
dc.subject.keywordsmusculoskeletal pain
dc.subject.keywordsrandomised controlled trial
dc.titleEffect of Different Exercise Training Intensities on Musculoskeletal and Neuropathic Pain in Inactive Individuals with Type 2 Diabetes - Preliminary Randomised Controlled Trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCox, ER; Gajanand, T; Burton, NW; Coombes, JS; Coombes, BK, Effect of Different Exercise Training Intensities on Musculoskeletal and Neuropathic Pain in Inactive Individuals with Type 2 Diabetes - Preliminary Randomised Controlled Trial, Diabetes Research and Clinical Practice, 2020, 164
dcterms.dateAccepted2020-04-21
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-05-11T01:05:52Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2020 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCoombes, Brooke K.
gro.griffith.authorBurton, Nicola W.


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