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dc.contributor.authorNevagi, Reshma J
dc.contributor.authorDai, Wei
dc.contributor.authorKhalil, Zeinab G
dc.contributor.authorHussein, Waleed M
dc.contributor.authorCapon, Robert J
dc.contributor.authorSkwarczynski, Mariusz
dc.contributor.authorToth, Istvan
dc.date.accessioned2020-05-11T04:12:13Z
dc.date.available2020-05-11T04:12:13Z
dc.date.issued2019
dc.identifier.issn0968-0896
dc.identifier.doi10.1016/j.bmc.2019.05.033
dc.identifier.urihttp://hdl.handle.net/10072/393765
dc.description.abstractShort peptides derived from virulent pathogen proteins are promising antigens for the development of vaccines against infectious diseases. However, in order to mimic the danger signals associated with natural infection and stimulate an adaptive immune response, peptide antigens must be co-delivered with immune adjuvants. In this study, a group A streptococcus (GAS) M-protein derived B-cell epitope: J8, and universal T-helper epitope P25 containing peptides, were chemically coupled with different anionic amino acid-based polymers. The poly(anionic amino acid)-peptide antigen conjugates were mixed with trimethyl chitosan (TMC) to produce self-adjuvanting nanoparticulate vaccine candidates. TMC from two different sources were used to analyse their effect on immunogenicity. The nanoparticles produced from a peptide modified with 10 residues of polyglutamic acid and fungal TMC (NP5) stimulated production of the highest levels of serum antibodies in outbred mice. These antibodies were opsonic against all clinical GAS isolates tested.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom3082
dc.relation.ispartofpageto3088
dc.relation.ispartofissue14
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry
dc.relation.ispartofvolume27
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.titleSelf-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNevagi, RJ; Dai, W; Khalil, ZG; Hussein, WM; Capon, RJ; Skwarczynski, M; Toth, I, Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system, Bioorganic & Medicinal Chemistry, 2019, 27 (14), pp. 3082-3088
dc.date.updated2020-05-11T04:10:26Z
gro.hasfulltextNo Full Text
gro.griffith.authorNevagi, Reshma J.


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