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dc.contributor.authorBabl, FE
dc.contributor.authorFranklin, D
dc.contributor.authorSchlapbach, LJ
dc.contributor.authorOakley, E
dc.contributor.authorDalziel, S
dc.contributor.authorWhitty, JA
dc.contributor.authorNeutze, J
dc.contributor.authorFuryk, J
dc.contributor.authorCraig, S
dc.contributor.authorFraser, JF
dc.contributor.authorJones, M
dc.contributor.authorSchibler, A
dc.date.accessioned2020-05-11T04:39:01Z
dc.date.available2020-05-11T04:39:01Z
dc.date.issued2020
dc.identifier.issn1034-4810
dc.identifier.doi10.1111/jpc.14799
dc.identifier.urihttp://hdl.handle.net/10072/393770
dc.description.abstractAim: Nasal high-flow oxygen therapy is increasingly used in infants for supportive respiratory therapy in bronchiolitis. It is unclear whether enteral hydration is safe in children receiving high-flow. Methods: We performed a planned secondary analysis of a multi-centre, randomised controlled trial of infants aged <12 months with bronchiolitis and an oxygen requirement. Children were assigned to treatment with either high-flow or standard-oxygen therapy with optional rescue high-flow. We assessed adverse events based on how children on high-flow were hydrated: intravenously (IV), via bolus or continuous nasogastric tube (NGT) or orally. Results: A total of 505 patients on high-flow via primary study assignment (n = 408), primary treatment (n = 10) or as rescue therapy (n = 87) were assessed. While on high flow, 15 of 505 (3.0%) received only IV fluids, 360 (71.3%) received only enteral fluids and 93 (18.4%) received both IV and enteral fluids. The route was unknown in 37 (7.3%). Of the 453 high-flow infants hydrated enterally patients could receive one or more methods of hydration; 80 (15.8%) received NGT bolus, 217 (43.0%) NGT continuous, 118 (23.4%) both bolus and continuous, 32 (6.3%) received only oral hydration and 171 (33.9%) a mix of NGT and oral hydration. None of the patients receiving oral or NGT hydration on high-flow sustained pulmonary aspiration (0%; 95% confidence interval N/A); one patient had a pneumothorax (0.2%; 95% confidence interval 0.0–0.7%). Conclusions: The vast majority of children with hypoxic respiratory failure in bronchiolitis can be safely hydrated enterally during the period when they receive high-flow.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalJournal of Paediatrics and Child Health
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.keywordsbronchiolitis
dc.subject.keywordsenteral hydration
dc.subject.keywordshigh-flow
dc.titleEnteral hydration in high-flow therapy for infants with bronchiolitis: Secondary analysis of a randomised trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBabl, FE; Franklin, D; Schlapbach, LJ; Oakley, E; Dalziel, S; Whitty, JA; Neutze, J; Furyk, J; Craig, S; Fraser, JF; Jones, M; Schibler, A, Enteral hydration in high-flow therapy for infants with bronchiolitis: Secondary analysis of a randomised trial, Journal of Paediatrics and Child Health, 2020
dcterms.dateAccepted2020-01-05
dc.date.updated2020-05-11T02:37:35Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorFraser, John F.
gro.griffith.authorWhitty, Jennifer A.


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