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dc.contributor.authorRourke, Michelle F
dc.contributor.authorPhelan, Alexandra
dc.contributor.authorLawson, Charles
dc.date.accessioned2020-05-12T04:41:43Z
dc.date.available2020-05-12T04:41:43Z
dc.date.issued2020
dc.identifier.issn1087-0156
dc.identifier.doi10.1038/s41587-020-0518-z
dc.identifier.urihttp://hdl.handle.net/10072/393808
dc.description.abstractTo the editor — In January 2018, PLOS ONE published the chemical synthesis of horsepox virus (HPXV) by a group of privately funded Canadian researchers. The authors state that “[s]ince HPXV may be extinct and the only specimen of HPXV that has been identified is unavailable for investigation, we explored whether HPXV could be obtained by large-scale gene synthesis.”1 The DNA sequence of the HPXV genome was published2 in 2006 and is publicly available in the US National Institutes of Health GenBank database. The Canadian researchers used the HPXV genome sequence as the digital template to ‘rematerialize’ the virus using DNA fragments ordered from a commercial provider in Germany. Viruses from the genus Orthopox have particular genetic structures (like terminal hairpin loops) that make them difficult to both sequence and reverse engineer, but the Canadian group overcame such technical difficulties using a helper virus, recreating a “faithful copy” of the HPXV template1.
dc.description.sponsorshipCSIRO
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom537
dc.relation.ispartofpageto539
dc.relation.ispartofjournalNature Biotechnology
dc.relation.ispartofvolume38
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchSynthetic biology
dc.subject.fieldofresearchEnvironmental and resources law
dc.subject.fieldofresearchInternational and comparative law
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode310113
dc.subject.fieldofresearchcode4802
dc.subject.fieldofresearchcode4803
dc.titleAccess and benefit-sharing following the synthesis of horsepox virus
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationRourke, MF; Phelan, A; Lawson, C, Access and benefit-sharing following the synthesis of horsepox virus., Nature Biotechnology, 2020, 38, pages 537–539.
dc.date.updated2020-05-12T04:20:09Z
gro.hasfulltextNo Full Text
gro.griffith.authorRourke, Michelle F.
gro.griffith.authorLawson, Charles


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