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dc.contributor.authorDasgupta, Paramita
dc.contributor.authorHenshaw, Chloe
dc.contributor.authorYoulden, Danny R
dc.contributor.authorAitken, Joanne F
dc.contributor.authorSullivan, Ashleigh
dc.contributor.authorIrving, Helen
dc.contributor.authorBaade, Peter D
dc.date.accessioned2020-05-13T01:57:18Z
dc.date.available2020-05-13T01:57:18Z
dc.date.issued2020
dc.identifier.issn0269-5022
dc.identifier.doi10.1111/ppe.12671
dc.identifier.urihttp://hdl.handle.net/10072/393827
dc.description.abstractBackground: Childhood liver cancers are relatively rare, hence inferences on incidence trends over time are limited by lack of precision in most studies. Objective: To conduct a systematic review and meta-analysis of published contemporary trends on childhood liver cancer incidence rates worldwide. Data sources: PubMed, EMBASE, CINAHL, Web of Science. Study selection and data extraction: English-language peer-reviewed articles published from 1 January 2008 to 1 December 2019 that presented quantitative estimates of incidence trends for childhood liver cancer and diagnostic subgroups. Review was conducted per PRISMA guidelines. Two authors independently extracted data and critically assessed studies. Synthesis: Random effects meta-analysis models were used to estimate pooled incidence trends by diagnostic subgroups. Heterogeneity was measured using the Q and I2 statistics and publication bias evaluated using Egger’s test. Results: Eighteen studies were included, all based on population-based cancer registries. Trends were reported on average for 18 years. Overall pooled estimates of the annual percentage change (APC) were 1.4 (95% confidence interval [CI] 0.5, 2.3) for childhood liver cancers, 2.8 (95% CI 1.8, 3.8) for hepatoblastoma and −3.0 (95% CI −11.0, 4.9) for hepatocellular carcinoma. Sub-group analysis by region indicated increasing trends for childhood liver cancers in North America/Europe/Australia (APC 1.7, 95% CI 0.7, 2.8) whereas corresponding trends were stable in Asia (APC 1.4, 95%CI −0.3, 2.7). Publication bias was not detected for any of these analyses. The I2 statistic indicated that the heterogeneity among included studies was low for combined liver cancers, moderate for hepatoblastoma and high for hepatocellular carcinoma. Conclusions: Incidence is increasing for childhood liver cancers and the most commonly diagnosed subgroup hepatoblastoma. Lack of knowledge of the etiology of childhood liver cancers limited the ability to understand the reasons for observed incidence trends. This review highlighted the need for ongoing monitoring of incidence trends and etiological studies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherWiley
dc.relation.ispartofjournalPaediatric and Perinatal Epidemiology
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPublic, Environmental & Occupational Health
dc.subject.keywordsObstetrics & Gynecology
dc.titleGlobal trends in incidence rates of childhood liver cancers: A systematic review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDasgupta, P; Henshaw, C; Youlden, DR; Aitken, JF; Sullivan, A; Irving, H; Baade, PD, Global trends in incidence rates of childhood liver cancers: A systematic review and meta-analysis, Paediatric and Perinatal Epidemiology, 2020
dcterms.dateAccepted2020-02-16
dc.date.updated2020-05-12T22:55:57Z
gro.description.notepublicThis publication was entered as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorDasgupta, Paramita
gro.griffith.authorYoulden, Danny R.
gro.griffith.authorBaade, Peter D.
gro.griffith.authorAitken, Joanne


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