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dc.contributor.authorNeale, Peta A
dc.contributor.authorFeliers, Cedric
dc.contributor.authorGlauch, Lisa
dc.contributor.authorKönig, Maria
dc.contributor.authorLecarpentier, Caroline
dc.contributor.authorSchlichting, Rita
dc.contributor.authorThibert, Sylvie
dc.contributor.authorEscher, Beate I
dc.date.accessioned2020-05-19T00:32:00Z
dc.date.available2020-05-19T00:32:00Z
dc.date.issued2020
dc.identifier.issn2053-1400
dc.identifier.doi10.1039/C9EW00987F
dc.identifier.urihttp://hdl.handle.net/10072/393966
dc.description.abstractSurface waters feeding water treatment plants (WTPs) can contain organic micropollutants, which are typically removed during treatment, while disinfection by-products (DBPs) can form after disinfection. The complex mixtures of chemicals in drinking water imply that targeted chemical analysis cannot capture all chemicals present, though in vitro bioassays can be applied alongside chemical analysis to monitor the total chemical burden. The current study applied bioassays indicative of hormone receptor-mediated effects to evaluate micropollutant removal during treatment, while bioassays indicative of adaptive stress responses and mutagenicity were applied to assess DBP formation. Water was extracted with solid-phase extraction from three WTPs using different treatment processes including biological treatment, nanofiltration and ozonation. Of the studied hormone receptors, only estrogenic activity was detected in the source waters feeding the WTPs, with all treatment processes able to remove estrogenic activity in the produced water completely or just above the detection limit. The oxidative stress response and NF-κB response for inflammation were detected in both source and treated water samples, with formed DBPs contributing to the increase in oxidative stress response. None of the samples induced the p53 response for genotoxicity or had a response in the Ames mutagenicity assay. The effects in the produced water were compared to effect-based trigger values (EBT) for activation of estrogenic activity and oxidative stress response, with the observed effect over 10 times lower than the available EBTs. This emphasises the high quality of the produced drinking water and the value of applying in vitro bioassays for water quality monitoring.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.ispartofjournalEnvironmental Science: Water Research & Technology
dc.subject.fieldofresearchEnvironmental Sciences
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchCivil Engineering
dc.subject.fieldofresearchEnvironmental Engineering
dc.subject.fieldofresearchcode05
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0905
dc.subject.fieldofresearchcode0907
dc.titleApplication of in vitro bioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationNeale, PA; Feliers, C; Glauch, L; König, M; Lecarpentier, C; Schlichting, R; Thibert, S; Escher, BI, Application of in vitro bioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection, Environmental Science: Water Research & Technology
dc.date.updated2020-05-18T07:00:36Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication was entered as an advanced online version.
gro.rights.copyright© 2020 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorNeale, Peta A.
gro.griffith.authorEscher, Beate


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