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  • Isotope metallomics approaches for medical research

    Author(s)
    Mahan, Brandon
    Chung, Roger S
    Pountney, Dean L
    Moynier, Frédéric
    Turner, Simon
    Griffith University Author(s)
    Pountney, Dean L.
    Year published
    2020
    Metadata
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    Abstract
    Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other "-omics" sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter category has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics-e.g. cancer, neurodegeneration, osteoporosis-as well ...
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    Metallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other "-omics" sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter category has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics-e.g. cancer, neurodegeneration, osteoporosis-as well as their utility in deciphering the underlying mechanisms of such diseases. These pioneering works indicate an enormous wealth of potential and provide a call to action for researchers to combine and leverage expertise and resources to create a clear and meaningful path forward. Doing so with efficacy and impact will require not only building on existing research, but also broadening collaborative networks, bolstering and deepening cross-disciplinary channels, and establishing unified and realizable objectives. The aim of this review is to briefly summarize the field and its underpinnings, provide a directory of the state of the art, outline the most encouraging paths forward, including their limitations, outlook and speculative upcoming breakthroughs, and finally to offer a vision of how to cultivate isotope metallomics for an impactful future.
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    Journal Title
    Cellular and Molecular Life Sciences
    DOI
    https://doi.org/10.1007/s00018-020-03484-0
    Note
    This publication was entered as an advanced online version.
    Subject
    Biochemistry and cell biology
    Zoology
    Clinical sciences
    Biomarkers
    Disease diagnostics
    Geochemistry
    Isotope metallomics
    Metallomics
    Publication URI
    http://hdl.handle.net/10072/394187
    Collection
    • Journal articles

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