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dc.contributor.authorMahan, Brandon
dc.contributor.authorChung, Roger S
dc.contributor.authorPountney, Dean L
dc.contributor.authorMoynier, Frédéric
dc.contributor.authorTurner, Simon
dc.date.accessioned2020-05-27T04:35:07Z
dc.date.available2020-05-27T04:35:07Z
dc.date.issued2020
dc.identifier.issn1420-9071
dc.identifier.doi10.1007/s00018-020-03484-0
dc.identifier.urihttp://hdl.handle.net/10072/394187
dc.description.abstractMetallomics is a rapidly evolving field of bio-metal research that integrates techniques and perspectives from other "-omics" sciences (e.g. genomics, proteomics) and from research vocations further afield. Perhaps the most esoteric of this latter category has been the recent coupling of biomedicine with element and isotope geochemistry, commonly referred to as isotope metallomics. Over the course of less than two decades, isotope metallomics has produced numerous benchmark studies highlighting the use of stable metal isotope distribution in developing disease diagnostics-e.g. cancer, neurodegeneration, osteoporosis-as well as their utility in deciphering the underlying mechanisms of such diseases. These pioneering works indicate an enormous wealth of potential and provide a call to action for researchers to combine and leverage expertise and resources to create a clear and meaningful path forward. Doing so with efficacy and impact will require not only building on existing research, but also broadening collaborative networks, bolstering and deepening cross-disciplinary channels, and establishing unified and realizable objectives. The aim of this review is to briefly summarize the field and its underpinnings, provide a directory of the state of the art, outline the most encouraging paths forward, including their limitations, outlook and speculative upcoming breakthroughs, and finally to offer a vision of how to cultivate isotope metallomics for an impactful future.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofjournalCellular and Molecular Life Sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3202
dc.subject.keywordsBiomarkers
dc.subject.keywordsDisease diagnostics
dc.subject.keywordsGeochemistry
dc.subject.keywordsIsotope metallomics
dc.subject.keywordsMetallomics
dc.titleIsotope metallomics approaches for medical research
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMahan, B; Chung, RS; Pountney, DL; Moynier, F; Turner, S, Isotope metallomics approaches for medical research, Cellular and Molecular Life Sciences, 2020
dcterms.dateAccepted2020-02-17
dc.date.updated2020-05-27T04:19:48Z
gro.description.notepublicThis publication was entered as an advanced online version.
gro.hasfulltextNo Full Text
gro.griffith.authorPountney, Dean L.


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