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  • Addition of Povidone-Iodine to Fluoride Varnish for Dental Caries: A Randomized Clinical Trial

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    Author(s)
    Milgrom, P
    Tut, O
    Rothen, M
    Mancl, L
    Gallen, M
    Tanzer, JM
    Griffith University Author(s)
    Tut, Ohnmar
    Year published
    2020
    Metadata
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    Abstract
    Introduction: Dental caries is the most common chronic childhood disease. Products of metabolism by bacteria populating the tooth surface induce development and progression of cavities. Objectives: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design. Methods: The site was Pohnpei State, Federated States of Micronesia. The study population was healthy children 49 to 84 mo old who were ...
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    Introduction: Dental caries is the most common chronic childhood disease. Products of metabolism by bacteria populating the tooth surface induce development and progression of cavities. Objectives: We sought to determine whether a polyvinylpyrrolidone-iodine (PVP-I; povidone-iodine) and NaF topical varnish was superior to one containing only NaF in prevention of new dental caries lesions in a single-center randomized active-controlled trial based on a double-blind, parallel-group design. Methods: The site was Pohnpei State, Federated States of Micronesia. The study population was healthy children 49 to 84 mo old who were enrolled in early childhood education: 284 were randomized (1:1 allocation), and 273 were included in year 1 analysis and 262 in year 2. The test varnish contained 10% PVP-I and 5.0% NaF. The comparator contained only 5.0% NaF but was otherwise identical. Varnishes were applied every 3 mo during 2 y. The primary outcome was the surface-level primary molar caries lesion increment (d2-4mfs) at 2 y. Caries lesion increments from baseline to year 1 and year 2 were compared between conditions with log-linear regression, adjusting for age and sex and whether the tooth was sound at baseline (free of caries lesions). Results: At year 1, the caries lesion increment for primary molars sound at baseline was 0.9 surfaces (SD = 1.5) for the test varnish versus 1.8 (SD = 2.2) for the comparator varnish with fluoride alone (adjusted rate ratio, 0.50; 95% CI, 0.31 to 0.81; P = .005). At year 2, the caries lesion increment for primary molars sound at baseline was 2.3 surfaces (SD = 2.8) for the test varnish as compared with 3.3 (SD = 2.7) for the comparator (adjusted rate ratio, 0.74; 95% CI, 0.52 to 1.03; P = .073). Teeth that were already cavitated at baseline did not show a preventive effect. There were no harms. Conclusions: A dental varnish containing PVP-I and NaF is effective in the primary prevention of cavities in the primary dentition (NCT03082196). Knowledge Transfer Statement: This study demonstrates that periodic application of a varnish containing NaF and PVP-I is effective in prevention of caries lesions and useful in assessing the potential of combined treatment.
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    Journal Title
    JDR Clinical & Translational Research
    DOI
    https://doi.org/10.1177/2380084420922968
    Note
    This publication has been entered into Griffith Research Online as an Advanced Online Version.
    Subject
    Dentistry
    Micronesia
    anti-infective agents local
    child
    drug monitoring
    sodium fluoride topical preparation
    Publication URI
    http://hdl.handle.net/10072/394204
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    • Journal articles

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