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dc.contributor.authorAlberto, L
dc.contributor.authorAitken, LM
dc.contributor.authorWalker, RM
dc.contributor.authorPálizas, F
dc.contributor.authorMarshall, AP
dc.date.accessioned2020-06-01T05:33:52Z
dc.date.available2020-06-01T05:33:52Z
dc.date.issued2020
dc.identifier.issn1464-3677
dc.identifier.doi10.1093/intqhc/mzaa059
dc.identifier.urihttp://hdl.handle.net/10072/394268
dc.description.abstractOBJECTIVE: The aim of this study was to evaluate the outcomes of implementing a sepsis screening (SS) tool based on the quick Sequential [Sepsis-Related] Organ Failure Assessment (qSOFA) and the presence of confirmed/suspected infection. The implementation of the 6-hour (6-h) bundle was also evaluated. DESIGN: Interrupted times series with prospective data collection. SETTING: Five hospital wards in a developing nation, Argentina. PARTICIPANTS: 1151 patients (≥18 years) recruited within 24-48 hours of hospital admission. INTERVENTION: The qSOFA-based SS tool and the 6-h bundle. MAIN OUTCOME MEASURES: The primary outcome was the timing of implementation of the first 6-h bundle element. Secondary outcomes were related to the adherence to the screening procedures. RESULTS: Of 1151 patients, 145 (12.6%) met the qSOFA-based SS tool criteria, among them intervention (39/64) patients received the first 6-h bundle element earlier (median 8 hours; 95% CI: 0.1-16) than baseline (48/81) patients (median 22 hours; 95% CI: 3-41); these times, however, did not differ significantly (p = 0.525). Overall, 47 (4.1%) patients had sepsis; intervention patients (18/25) received the first 6-h bundle element sooner (median 5 hours; 95% CI: 4-6) than baseline patients (15/22) did (median 12 hours; 95% CI: 0-33), however times were not significantly different (p = 0.470). While intervention patients were screened regularly, only one-third of patients that required sepsis alerts had them activated. CONCLUSION: The implementation of the qSOFA-based SS tool resulted in early, but not significantly improved, provision of 6-h bundle care. Screening procedures were regularly conducted, but sepsis alerts rarely activated. Further research is needed to better understand implementation of sepsis care in developing settings.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofjournalInternational Journal for Quality in Health Care
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.subject.keywords6-h bundle
dc.subject.keywordsdeveloping nation
dc.subject.keywordshospital ward
dc.subject.keywordsimplementation
dc.subject.keywordsqSOFA
dc.titleImplementing a quick Sequential (Sepsis-Related) Organ Failure Assessment sepsis screening tool: an interrupted times series study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAlberto, L; Aitken, LM; Walker, R; Pálizas, F; Marshall, AP, Implementing a quick Sequential (Sepsis-Related) Organ Failure Assessment sepsis screening tool: an interrupted times series study, International Journal for Quality in Health Care, 2020
dcterms.dateAccepted2020-05-07
dc.date.updated2020-06-01T00:19:33Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication was entered as an advanced online version.
gro.rights.copyright© 2020 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal for Quality in Health Care following peer review. The definitive publisher-authenticated version Implementing a quick Sequential (Sepsis-Related) Organ Failure Assessment sepsis screening tool: an interrupted times series study, International Journal for Quality in Health Care, 2020 is available online at: https://doi.org/10.1093/intqhc/mzaa059.
gro.hasfulltextFull Text
gro.griffith.authorMarshall, Andrea
gro.griffith.authorAitken, Leanne M.
gro.griffith.authorWalker, Rachel M.
gro.griffith.authorAlberto, Laura M.


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