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dc.contributor.authorZhou, Renwu
dc.contributor.authorWang, Peiyu
dc.contributor.authorGuo, Yanru
dc.contributor.authorDai, Xiaofeng
dc.contributor.authorXiao, Shaoqing
dc.contributor.authorFang, Zhi
dc.contributor.authorSpeight, Robert
dc.contributor.authorThompson, Erik Walter W
dc.contributor.authorCullen, Patrick J
dc.contributor.authorOstrikov, Kostya Ken
dc.date.accessioned2020-06-02T00:07:40Z
dc.date.available2020-06-02T00:07:40Z
dc.date.issued2019
dc.identifier.issn2040-3364
dc.identifier.doi10.1039/c9nr04951g
dc.identifier.urihttp://hdl.handle.net/10072/394289
dc.description.abstractOxidative stress in cells caused by the accumulation of reactive oxygen species (ROS) is a common cause of cell function degeneration, cell death and various diseases. Efficient, robust and inexpensive nanoparticles (nanoenzymes) capable of scavenging/detoxifying ROS even in harsh environments are attracting strong interest. Prussian blue analogues (PBAs), a prominent group of metalorganic nanoparticles (NPs) with the same cyanometalate structure as the traditional and commonly used Prussian blue (PB), have long been envisaged to mimic enzyme activities for ROS scavenging. However, their biological toxicity, especially potential effects on living beings during practical application, has not yet been fully investigated. Here we reveal the enzyme-like activity of FeCo-PBA NPs, and for the first time investigate the effects of FeCo-PBA on cell viability and growth. We elucidate the effect of the nanoenzyme on the ethanol-production efficacy of a typical model organism, the engineered industrial strain Saccharomyces cerevisiae. We further demonstrate that FeCo-PBA NPs have almost no cytotoxicity on the cells over a broad dosage range (0-100 μg mL-1), while clearly boosting the yeast fermentation efficiency by mitigating oxidative stress. Atmospheric pressure cold plasma (APCP) pretreatment is used as a multifunctional environmental stress produced by the plasma reactive species. While the plasma enhances the cellular uptake of NPs, FeCo-PBA NPs protect the cells from the oxidative stress induced by both the plasma and the fermentation processes. This synergistic effect leads to higher secondary metabolite yields and energy production. Collectively, this study confirms the positive effects of PBA nanoparticles in living cells through ROS scavenging, thus potentially opening new ways to control the cellular machinery in future nano-biotechnology and nano-biomedical applications.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofpagefrom19497
dc.relation.ispartofpageto19505
dc.relation.ispartofissue41
dc.relation.ispartofjournalNanoscale
dc.relation.ispartofvolume11
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode34
dc.subject.keywordsScience & Technology
dc.subject.keywordsChemistry, Multidisciplinary
dc.subject.keywordsNanoscience & Nanotechnology
dc.titlePrussian blue analogue nanoenzymes mitigate oxidative stress and boost bio-fermentation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhou, R; Wang, P; Guo, Y; Dai, X; Xiao, S; Fang, Z; Speight, R; Thompson, EWW; Cullen, PJ; Ostrikov, KK, Prussian blue analogue nanoenzymes mitigate oxidative stress and boost bio-fermentation, Nanoscale, 2019, 11 (41), pp. 19497-19505
dc.date.updated2020-06-02T00:06:29Z
gro.hasfulltextNo Full Text
gro.griffith.authorOstrikov, Ken


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