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dc.contributor.authorPlatts, David G
dc.contributor.authorShiino, Kenji
dc.contributor.authorChan, Jonathan
dc.contributor.authorBurstow, Darryl J
dc.contributor.authorScalia, Gregory M
dc.contributor.authorFraser, John F
dc.date.accessioned2020-06-02T03:06:22Z
dc.date.available2020-06-02T03:06:22Z
dc.date.issued2019
dc.identifier.issn2055-0464
dc.identifier.doi10.1530/ERP-18-0071
dc.identifier.urihttp://hdl.handle.net/10072/394306
dc.description.abstractBackground: Transthoracic echocardiography (TTE) plays a fundamental role in the management of patients supported with extra-corporeal membrane oxygenation (ECMO). In light of fluctuating clinical states, serial monitoring of cardiac function is required. Formal quantification of ventricular parameters and myocardial mechanics offer benefit over qualitative assessment. The aim of this research was to compare unenhanced (UE) versus contrast-enhanced (CE) quantification of myocardial function and mechanics during ECMO in a validated ovine model. Methods: Twenty-four sheep were commenced on peripheral veno-venous ECMO. Acute smoke-induced lung injury was induced in 21 sheep (3 controls). CE-TTE with Definity using Cadence Pulse Sequencing was performed. Two readers performed image analysis with TomTec Arena. End diastolic area (EDA, cm2), end systolic area (ESA, cm2), fractional area change (FAC, %), endocardial global circumferential strain (EGCS, %), myocardial global circumferential strain (MGCS, %), endocardial rotation (ER, degrees) and global radial strain (GRD, %) were evaluated for UE-TTE and CE-TTE. Results: Full data sets are available in 22 sheep (92%). Mean CE EDA and ESA were significantly larger than in unenhanced images. Mean FAC was almost identical between the two techniques. There was no significant difference between UE and CE EGCS, MGCS and ER. There was significant difference in GRS between imaging techniques. Unenhanced inter-observer variability was from 0.48–0.70 but significantly improved to 0.71–0.89 for contrast imaging in all echocardiographic parameters. Conclusion: Semi-automated methods of myocardial function and mechanics using CE-TTE during ECMO was feasible and similar to UE-TTE for all parameters except ventricular areas and global radial strain. Addition of contrast significantly decreased inter-observer variability of all measurements.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioScientifica
dc.relation.ispartofpagefrom25
dc.relation.ispartofpageto35
dc.relation.ispartofissue2
dc.relation.ispartofjournalEcho Research and Practice
dc.relation.ispartofvolume6
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCardiac & Cardiovascular Systems
dc.subject.keywordsCardiovascular System & Cardiology
dc.subject.keywordstransthoracic echocardiography
dc.titleEchocardiographic assessment of myocardial function and mechanics during veno-venous extracorporeal membrane oxygenation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPlatts, DG; Shiino, K; Chan, J; Burstow, DJ; Scalia, GM; Fraser, JF, Echocardiographic assessment of myocardial function and mechanics during veno-venous extracorporeal membrane oxygenation, Echo Research and Practice, 2019, 6 (2), pp. 25-35
dcterms.dateAccepted2019-04-03
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-02T03:00:13Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.
gro.griffith.authorShiino, Kenji
gro.griffith.authorChan, Jonathan H.


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