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dc.contributor.authorDe Zoete, RMJ
dc.contributor.authorMcAuley, JH
dc.contributor.authorArmfield, NR
dc.contributor.authorSterling, M
dc.date.accessioned2020-06-07T22:12:08Z
dc.date.available2020-06-07T22:12:08Z
dc.date.issued2020
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2019-034846
dc.identifier.urihttp://hdl.handle.net/10072/394446
dc.description.abstractIntroduction: Neck pain is a global burdensome problem, with a large proportion of neck pain cases becoming chronic. Although physical exercise is a commonly prescribed treatment, the evidence on the effectiveness of isolated exercise interventions remains limited. Traditional pairwise randomised controlled trials (RCTs) and meta-analyses are limited in only comparing two interventions. This protocol describes the design of a network meta-analysis, which enables a comparative investigation of all physical exercise interventions for which RCTs are available. We aim to systematically compare the effectiveness of different types of physical exercise in people with chronic non-specific neck pain. Methods and analysis: Nine electronic databases (AMED, CINAHL, Cochrane Central Register of Controlled Trials, Embase, MEDLINE, Physiotherapy Evidence Database, PsycINFO, Scopus and SPORTDiscus) were searched for RCTs from inception to 12 March 2019. Titles and abstract firstly, and full-text papers secondly, will be screened by two reviewers. Data will be extracted by two reviewers. The primary outcome measure is effectiveness of the intervention. Methodological quality of included studies will be assessed by two reviewers using the PEDro scale. The overall quality of evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework, which has been adapted for network meta-analyses. The available evidence will be summarised using a network diagram. A contribution matrix will be presented to allow assessment of direct and indirect evidence. Forest plots will be constructed to visualise effects of all included exercise interventions. Pairwise effect sizes will be calculated by including all evidence available in the network. Effect measures for treatments that have not been compared in a pairwise RCT can be compared indirectly by contrasting effect sizes of comparisons with a common comparator. Ethics and dissemination: This work synthesises evidence from previously published studies and does not require ethics review or approval. A manuscript describing the findings will be submitted for publication in a peer-reviewed scientific journal. PROSPERO registration number CRD42019126523.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofissue5
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.subject.keywordsmusculoskeletal disorders
dc.subject.keywordspain management
dc.subject.keywordsrehabilitation medicine
dc.titleThe comparative effectiveness of physical exercise interventions in individuals with chronic non-specific neck pain: Protocol for a network meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDe Zoete, RMJ; McAuley, JH; Armfield, NR; Sterling, M, The comparative effectiveness of physical exercise interventions in individuals with chronic non-specific neck pain: Protocol for a network meta-analysis, BMJ Open, 2020, 10 (5)
dcterms.licensehttp://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2020-06-05T05:24:01Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Authors, 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial
gro.hasfulltextFull Text
gro.griffith.authorSterling, Michele


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