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dc.contributor.authorKeijzers, Gerben
dc.contributor.authorMacdonald, Stephen PJ
dc.contributor.authorUdy, Andrew A
dc.contributor.authorArendts, Glenn
dc.contributor.authorBailey, Michael
dc.contributor.authorBellomo, Rinaldo
dc.contributor.authorBlecher, Gabriel E
dc.contributor.authorBurcham, Jonathon
dc.contributor.authorCoggins, Andrew R
dc.contributor.authorDelaney, Anthony
dc.contributor.authorFatovich, Daniel M
dc.contributor.authorFraser, John F
dc.contributor.authorHarley, Amanda
dc.contributor.authorJones, Peter
dc.contributor.authorKinnear, Frances B
dc.contributor.authorMay, Katya
dc.contributor.authorPeake, Sandra
dc.contributor.authorTaylor, David McD
dc.contributor.authorWilliams, Patricia
dc.contributor.authorKhanh, Nguyen
dc.contributor.authorFoong, Lai Heng
dc.contributor.authorHullick, Carolyn
dc.contributor.authorMcNulty, Richard
dc.contributor.authorNa, Andrew
dc.contributor.authorTrethewy, Christopher
dc.contributor.authorLutze, Lucy
dc.contributor.authorZhang, Michael
dc.contributor.authorCowan, Tim
dc.contributor.authorMiddleton, Paul
dc.contributor.authorAvis, Suzanne
dc.contributor.authorVidler, Sam
dc.contributor.authorSalter, Mark
dc.contributor.authorJanes, Simon
dc.contributor.authorHarwood, Tom
dc.contributor.authorOliver, Matthew
dc.contributor.authorJazayeri, Farzad
dc.contributor.authorJones, Sarah
dc.contributor.authorDavoren, Michael
dc.contributor.authorCoggins, Andrew
dc.contributor.authorPradhananga, Bibhu
dc.contributor.authorNewby, Lynette
dc.contributor.authorBeck, Sierra
dc.contributor.authorSandleback, Brad
dc.contributor.authorRabas, Sophie
dc.contributor.authorHarger, Simon
dc.contributor.authorTan, Eunicia
dc.contributor.authorSong, Rima
dc.contributor.authorGutenstein, Marc
dc.contributor.authorMunro, Andrew
dc.contributor.authorConnely, Michael
dc.contributor.authorGoodson, Jennifer
dc.contributor.authorMclean, Alastair
dc.contributor.authorBrabyn, Christine
dc.contributor.authorMukerji, Saptarshi
dc.contributor.authorSimmonds, Harnah
dc.contributor.authorYoung, Paul
dc.contributor.authorSugeng, Yulia
dc.contributor.authorBird, Cheryl
dc.contributor.authorMcConnell, Amanda
dc.contributor.authorHenderson, Peter
dc.contributor.authorJohnson, David
dc.contributor.authorPerez, Siegfried
dc.contributor.authorMahani, Abbas
dc.contributor.authorOrda, Ulrich
dc.contributor.authorThom, Ogilvie
dc.contributor.authorRoberts, Kym
dc.contributor.authorKinnear, Frances
dc.contributor.authorHazelwood, Sarah
dc.contributor.authorHanh, Pham
dc.contributor.authorEley, Rob
dc.contributor.authorLivesay, Georgia
dc.contributor.authorDevlin, Michael
dc.contributor.authorMurdoch, Ian
dc.contributor.authorWood, Erik
dc.contributor.authorWilliams, Julian
dc.contributor.authorBrown, Nathan
dc.contributor.authorKing, Alex
dc.contributor.authorSadewasser, Jan
dc.contributor.authorJones, Leonie
dc.contributor.authorGangathimmaiah, Vinay
dc.contributor.authorManudhane, Anit
dc.contributor.authorHaustead, Daniel
dc.contributor.authorAscencio-Lane, Juan-Carlos
dc.contributor.authorBuntine, Paul
dc.contributor.authorWalker, Katie
dc.contributor.authorPouryahya, Pourya
dc.contributor.authorCrompton, Daniel
dc.contributor.authorSultana, Ron
dc.contributor.authorCampbell, Timothy
dc.contributor.authorDwyer, Rosamond
dc.contributor.authorBlecher, Gabriel
dc.contributor.authorKnott, Jonathan
dc.contributor.authorMitra, Biswadev
dc.contributor.authorLuckhoff, Carl
dc.contributor.authorYoung, Russel
dc.contributor.authorRudling, Natalie
dc.contributor.authorMukherjee, Ashes
dc.contributor.authorDyke, Kerry-Lee
dc.contributor.authorParker, Casey
dc.contributor.authorCooper, Alannah
dc.contributor.authorNagree, Yusuf
dc.contributor.authorKoay, Keng
dc.contributor.authorKruger, Coert
dc.contributor.authorGhedina, Nicole
dc.contributor.authorSmedley, Ben
dc.contributor.authorMacdonald, Stephen
dc.contributor.authorHamersley, Helen
dc.date.accessioned2020-06-08T00:37:00Z
dc.date.available2020-06-08T00:37:00Z
dc.date.issued2020
dc.identifier.issn1742-6731
dc.identifier.doi10.1111/1742-6723.13469
dc.identifier.urihttp://hdl.handle.net/10072/394470
dc.description.abstractEmergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian College for Emergency Medicine Objectives: To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension. Methods: This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality. Results: A total of 4477 patients were screened and 591 were included with a mean (standard deviation) age of 62 (19) years, Acute Physiology and Chronic Health Evaluation II score 15.2 (6.6) and a median (interquartile range) systolic blood pressure of 94 mmHg (87–100). Median time to first intravenous antimicrobials was 77 min (42–148). A vasopressor infusion was commenced within 24 h in 177 (30.2%) patients, with noradrenaline the most frequently used (n = 138, 78%). A median of 2000 mL (1500–3000) of intravenous fluids was administered prior to commencing vasopressors. The total volume of fluid administered from pre-enrolment to 24 h was 4200 mL (3000–5661), with a range from 1000 to 12 200 mL. Two hundred and eighteen patients (37.1%) were admitted to an intensive care unit. Overall in-hospital mortality was 6.2% (95% confidence interval 4.4–8.5%). Conclusion: Current resuscitation practice in patients with sepsis and hypotension varies widely and occupies the spectrum between a restricted volume/earlier vasopressor and liberal fluid/later vasopressor strategy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalEmergency Medicine Australasia
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEmergency Medicine
dc.subject.keywordsemergency department
dc.subject.keywordsfluid therapy
dc.titleThe Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKeijzers, G; Macdonald, SPJ; Udy, AA; Arendts, G; Bailey, M; Bellomo, R; Blecher, GE; Burcham, J; Coggins, AR; Delaney, A; Fatovich, DM; Fraser, JF; Harley, A; Jones, P; et al, The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand, Emergency Medicine Australasia, 2020
dcterms.dateAccepted2020-01-07
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-08T00:05:48Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Emergency Medicine Australasia published by John Wiley & Sons Australia, Ltd on behalf of Australasian College for Emergency Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.
gro.griffith.authorKeijzers, Gerben


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