Show simple item record

dc.contributor.authorAlcock, Brian P
dc.contributor.authorRaphenya, Amogelang R
dc.contributor.authorLau, Tammy TY
dc.contributor.authorTsang, Kara K
dc.contributor.authorBouchard, Megane
dc.contributor.authorEdalatmand, Arman
dc.contributor.authorHuynh, William
dc.contributor.authorNguyen, Anna-Lisa
dc.contributor.authorCheng, Annie A
dc.contributor.authorLiu, Sihan
dc.contributor.authorMin, Sally Y
dc.contributor.authorMiroshnichenko, Anatoly
dc.contributor.authorTran, Hiu-Ki
dc.contributor.authorWerfalli, Rafik E
dc.contributor.authorNasir, Jalees A
dc.contributor.authorOloni, Martins
dc.contributor.authorSpeicher, David J
dc.contributor.authorFlorescu, Alexandra
dc.contributor.authorSingh, Bhavya
dc.contributor.authorFaltyn, Mateusz
dc.contributor.authorHernandez-Koutoucheva, Anastasia
dc.contributor.authorSharma, Arjun N
dc.contributor.authorBordeleau, Emily
dc.contributor.authorPawlowski, Andrew C
dc.contributor.authorZubyk, Haley L
dc.contributor.authorDooley, Damion
dc.contributor.authorGriffiths, Emma
dc.contributor.authorMaguire, Finlay
dc.contributor.authorWinsor, Geoff L
dc.contributor.authorBeiko, Robert G
dc.contributor.authorBrinkman, Fiona SL
dc.contributor.authorHsiao, William WL
dc.contributor.authorDomselaar, Gary
dc.contributor.authorMcArthur, Andrew G
dc.date.accessioned2020-06-08T00:50:43Z
dc.date.available2020-06-08T00:50:43Z
dc.date.issued2020
dc.identifier.issn0305-1048
dc.identifier.doi10.1093/nar/gkz935
dc.identifier.urihttp://hdl.handle.net/10072/394474
dc.description.abstractThe Comprehensive Antibiotic Resistance Database (CARD; https://card.mcmaster.ca) is a curated resource providing reference DNA and protein sequences, detection models and bioinformatics tools on the molecular basis of bacterial antimicrobial resistance (AMR). CARD focuses on providing high-quality reference data and molecular sequences within a controlled vocabulary, the Antibiotic Resistance Ontology (ARO), designed by the CARD biocuration team to integrate with software development efforts for resistome analysis and prediction, such as CARD's Resistance Gene Identifier (RGI) software. Since 2017, CARD has expanded through extensive curation of reference sequences, revision of the ontological structure, curation of over 500 new AMR detection models, development of a new classification paradigm and expansion of analytical tools. Most notably, a new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes. By adding these resistance variants to CARD, we are able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants. Here, we describe updates and recent expansions to CARD and its biocuration process, including new resources for community biocuration of AMR molecular reference data.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefromD517
dc.relation.ispartofpagetoD525
dc.relation.ispartofissueD1
dc.relation.ispartofjournalNucleic Acids Research
dc.relation.ispartofvolume48
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode41
dc.subject.fieldofresearchcode31
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsANTIMICROBIAL RESISTANCE
dc.subject.keywordsREAD ALIGNMENT
dc.titleCARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAlcock, BP; Raphenya, AR; Lau, TTY; Tsang, KK; Bouchard, M; Edalatmand, A; Huynh, W; Nguyen, A-L; Cheng, AA; Liu, S; Min, SY; Miroshnichenko, A; Tran, H-K; Werfalli, RE; Nasir, JA; Oloni, M; Speicher, DJ; Florescu, A; Singh, B; Faltyn, M; Hernandez-Koutoucheva, A; Sharma, AN; Bordeleau, E; Pawlowski, AC; Zubyk, HL; Dooley, D; Griffiths, E; Maguire, F; Winsor, GL; Beiko, RG; Brinkman, FSL; Hsiao, WWL; Domselaar, G; McArthur, AG, CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database, Nucleic Acids Research, 2020, 48 (D1), pp. D517-D525
dcterms.dateAccepted2019-10-08
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-08T00:46:51Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorSpeicher, David J.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record