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dc.contributor.authorDas, Plabon Kumar
dc.contributor.authorIslam, Farhadul
dc.contributor.authorLam, Alfred K
dc.date.accessioned2020-06-16T04:33:40Z
dc.date.available2020-06-16T04:33:40Z
dc.date.issued2020
dc.identifier.issn2073-4409
dc.identifier.doi10.3390/cells9061392
dc.identifier.urihttp://hdl.handle.net/10072/394670
dc.description.abstractCancer stem cells (CSCs) are the main culprits involved in therapy resistance and disease recurrence in colorectal carcinoma (CRC). Results using cell culture, animal models and tissues from patients with CRC suggest the indispensable roles of colorectal CSCs in therapeutic failure. Conventional therapies target proliferating and mature cancer cells, while CSCs are mostly quiescent and poorly differentiated, thereby they can easily survive chemotherapeutic insults. The aberrant activation of Wnt/β-catenin, Notch, Hedgehog, Hippo/YAP (Yes-associated protein) and phosphatidylinositol 3-kinase/protein kinase B facilitates CSCs with excessive self-renewal and therapy resistance property in CRC. CSCs survive the chemo-radiotherapies by escaping therapy mediated DNA damage via altering the cell cycle checkpoints, increasing DNA damage repair capacity and by an efficient scavenging of reactive oxygen species. Furthermore, dysregulations of miRNAs e.g., miR-21, miR-93, miR-203, miR-215, miR-497 etc., modulate the therapeutic sensitivity of colorectal CSCs by regulating growth and survival signalling. In addition, a reversible quiescent G0 state and the re-entering cell cycle capacity of colorectal CSCs can accelerate tumour regeneration after treatment. Moreover, switching to favourable metabolic signatures during a therapeutic regimen will add more complexity in therapeutic outcomes against CSCs. Therapeutic strategies targeting these underlying mechanisms of CSCs’ therapy resistance could provide a promising outcome, however, deep understanding and concerted research are necessary to design novel therapies targeting CSCs. To conclude, the understanding of these mechanisms of CSC in CRC could lead to the improved management of patients with CRC.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.relation.ispartofpagefrom1392
dc.relation.ispartofpageto1392
dc.relation.ispartofissue6
dc.relation.ispartofjournalCells
dc.relation.ispartofvolume9
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsDNA damage
dc.subject.keywordscancer stem cells
dc.subject.keywordscolorectal carcinoma
dc.subject.keywordsmicroRNAs
dc.subject.keywordssignalling pathways
dc.titleThe Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDas, PK; Islam, F; Lam, AK, The Roles of Cancer Stem Cells and Therapy Resistance in Colorectal Carcinoma, Cells, 2020, 9 (6), pp. 1392-1392
dcterms.dateAccepted2020-06-02
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-16T03:47:56Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 The Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorIslam, Farhad


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