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dc.contributor.authorLepletier, A
dc.contributor.authorMadore, J
dc.contributor.authorO'Donnell, JS
dc.contributor.authorJohnston, RL
dc.contributor.authorLi, XY
dc.contributor.authorMcDonald, E
dc.contributor.authorAhern, E
dc.contributor.authorKuchel, A
dc.contributor.authorEastgate, M
dc.contributor.authorPearson, SA
dc.contributor.authorMallardo, D
dc.contributor.authorAscierto, PA
dc.contributor.authorMassi, D
dc.contributor.authorMerelli, B
dc.contributor.authorMandala, M
dc.contributor.authorWilmott, JS
dc.contributor.authorMenzies, AM
dc.contributor.authorLeduc, C
dc.contributor.authorStagg, J
dc.contributor.authorRouty, B
dc.contributor.authorLong, GV
dc.contributor.authorScolyer, RA
dc.contributor.authorBald, T
dc.contributor.authorWaddell, N
dc.contributor.authorDougall, WC
dc.contributor.authorTeng, MWL
dc.contributor.authorSmyth, MJ
dc.date.accessioned2020-06-18T04:41:20Z
dc.date.available2020-06-18T04:41:20Z
dc.date.issued2020
dc.identifier.issn1078-0432
dc.identifier.doi10.1158/1078-0432.ccr-19-3925
dc.identifier.urihttp://hdl.handle.net/10072/394717
dc.description.abstractPurpose: Resistance to anti-PD1–based immune checkpoint blockade (ICB) remains a problem for the treatment of metastatic melanoma. Tumor cells as well as host myeloid cells can express the immune checkpoint ligand CD155 to regulate immune cell function. However, the effect of tumor CD155 on the immune context of human melanoma has not been well described. This observational study characterizes tumor CD155 ligand expression by metastatic melanoma tumors and correlates results with differences in immune cell features and response to ICB. Experimental Design: Pretreatment tumor specimens, from 155 patients with metastatic melanoma treated with ICB and from 50 patients treated with BRAF/MEK-directed targeted therapy, were assessed for CD155 expression by IHC. Intratumor T-cell features were analyzed using multiplex-immunohistofluorescence for CD8, PD1, and SOX10. Correlations were made between CD155 tumor level and bulk tumor RNA sequencing results, as well as clinical RECIST response and progression-free survival. Results: High pretreatment CD155 tumor levels correlated with high parenchymal PD1+CD8+/CD8+ T-cell ratios (PD1tR) and poor response to anti-PD1 therapy. In PDL1 negative tumors, high CD155 tumor expression was associated with patients who had poor response to combination anti-PD1/CTLA4 therapy. Conclusions: Our findings are the first to suggest that tumor CD155 supports an increase in the fraction of PD1+CD8+ T cells in anti-PD1 refractory melanoma tumors and, further, that targeting the CD155 pathway might improve response to anti-PD1 therapy for patients with metastatic melanoma.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for Cancer Research (AACR)
dc.relation.ispartofjournalClinical Cancer Research
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.titleTumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLepletier, A; Madore, J; O'Donnell, JS; Johnston, RL; Li, X-Y; McDonald, E; Ahern, E; Kuchel, A; Eastgate, M; Pearson, S-A; Mallardo, D; Ascierto, PA; Massi, D; Merelli, B; Mandala, M; Wilmott, JS; Menzies, AM; Leduc, C; Stagg, J; Routy, B; Long, GV; Scolyer, RA; Bald, T; Waddell, N; Dougall, WC; Teng, MWL; Smyth, MJ, Tumor CD155 expression is associated with resistance to anti-PD1 immunotherapy in metastatic melanoma, Clinical Cancer Research, 2020
dc.date.updated2020-06-17T05:32:20Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.rights.copyright© 2020 AACR. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorLepletier De Oliveira, Ailin


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