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dc.contributor.authorKhalilidehkordi, Elham
dc.contributor.authorClarke, Laura
dc.contributor.authorArnett, Simon
dc.contributor.authorBukhari, Wajih
dc.contributor.authorJimenez Sanchez, Sofia
dc.contributor.authorO'Gorman, Cullen
dc.contributor.authorSun, Jing
dc.contributor.authorPrain, Kerri M
dc.contributor.authorWoodhall, Mark
dc.contributor.authorSilvestrini, Roger
dc.contributor.authorBundell, Christine S
dc.contributor.authorAbernethy, David
dc.contributor.authorBhuta, Sandeep
dc.contributor.authorBlum, Stefan
dc.contributor.authorBoggild, Mike
dc.contributor.authorBoundy, Karyn
dc.contributor.authorBrew, Bruce J
dc.contributor.authorBrown, Matthew
dc.contributor.authorBrownlee, Wallace
dc.contributor.authorButzkueven, Helmut
dc.contributor.authorCarroll, William M
dc.contributor.authorChen, Celia
dc.contributor.authorCoulthard, Alan
dc.contributor.authorDale, Russell C
dc.contributor.authorDas, Chandi
dc.contributor.authorFabis-Pedrini, Marzena J
dc.contributor.authorFulcher, David
dc.contributor.authorGillis, David
dc.contributor.authorHawke, Simon
dc.contributor.authorHeard, Robert
dc.contributor.authorHenderson, Andrew PD
dc.contributor.authorHeshmat, Saman
dc.contributor.authorHodgkinson, Suzanne
dc.contributor.authorKilpatrick, Trevor J
dc.contributor.authorKing, John
dc.contributor.authorKneebone, Chris
dc.contributor.authorKornberg, Andrew J
dc.contributor.authorLechner-Scott, Jeannette
dc.contributor.authorLin, Ming-Wei
dc.contributor.authorLynch, Christopher
dc.contributor.authorMacdonell, Richard AL
dc.contributor.authorMason, Deborah F
dc.contributor.authorMcCombe, Pamela A
dc.contributor.authorPereira, Jennifer
dc.contributor.authorPollard, John D
dc.contributor.authorRamanathan, Sudarshini
dc.contributor.authorReddel, Stephen W
dc.contributor.authorShaw, Cameron
dc.contributor.authorSpies, Judith
dc.contributor.authorStankovich, James
dc.contributor.authorSutton, Ian
dc.contributor.authorVucic, Steve
dc.contributor.authorWalsh, Michael
dc.contributor.authorWong, Richard C
dc.contributor.authorYiu, Eppie M
dc.contributor.authorBarnett, Michael H
dc.contributor.authorKermode, Allan G
dc.contributor.authorMarriott, Mark P
dc.contributor.authorParratt, John
dc.contributor.authorSlee, Mark
dc.contributor.authorTaylor, Bruce V
dc.contributor.authorWilloughby, Ernest
dc.contributor.authorBrilot, Fabienne
dc.contributor.authorVincent, Angela
dc.contributor.authorWaters, Patrick
dc.contributor.authorBroadley, Simon A
dc.date.accessioned2020-06-19T00:44:34Z
dc.date.available2020-06-19T00:44:34Z
dc.date.issued2020
dc.identifier.issn1664-2295
dc.identifier.doi10.3389/fneur.2020.00537
dc.identifier.urihttp://hdl.handle.net/10072/394730
dc.description.abstractNeuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.relation.ispartofpagefrom537:1
dc.relation.ispartofpageto537:8
dc.relation.ispartofjournalFrontiers in Neurology
dc.relation.ispartofvolume11
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1701
dc.titleRelapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKhalilidehkordi, E; Clarke, L; Arnett, S; Bukhari, W; Jimenez Sanchez, S; O'Gorman, C; Sun, J; Prain, KM; Woodhall, M; Silvestrini, R; Bundell, CS; Bhuta, S; Heshmat, S; Broadley, SA, et al., Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation, Frontiers in Neurology, 11, pp. 537:1-537:8
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-17T11:30:30Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Khalilidehkordi, Clarke, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorSun, Jing
gro.griffith.authorBukhari, Wajih u.
gro.griffith.authorKhalilidehkordi, Ellie
gro.griffith.authorArnett, Simon
gro.griffith.authorClarke, Laura
gro.griffith.authorBroadley, Simon
gro.griffith.authorJimenez Sanchez, Sofia
gro.griffith.authorO'Gorman, Cullen
gro.griffith.authorBhuta, Sandeep
gro.griffith.authorHeshmat, Sam


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