dc.contributor.author | Dashwood, Alexander | |
dc.contributor.author | Rahman, Atifur | |
dc.contributor.author | Pavicic, Matthew | |
dc.date.accessioned | 2020-06-23T00:57:44Z | |
dc.date.available | 2020-06-23T00:57:44Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0195-668X | |
dc.identifier.doi | 10.1093/eurheartj/ehv070 | |
dc.identifier.uri | http://hdl.handle.net/10072/394793 | |
dc.description.abstract | A 72-year-old gentleman presented with right heart failure (RHF) from tricuspid insufficiency. He also noted episodes of diarrhoea and flushing. Echocardiogram showed severe tricuspid regurgitation (TR) with thickened tricuspid leaflets (Panel A). The subcostal view revealed a hepatic mass, which, following biopsy and evaluation of 5-hydroxytryptamine, was confirmed as metastatic carcinoid tumour (Panel B).
Carcinoid heart disease (CHD), namely TR, is the initial presentation of carcinoid tumours in up to 20% of patients. Serotonin, by activating the 5-HT(2B) receptor, induces fibrous tissue deposition on the endocardial surface of valvular cusps and cardiac chambers. Pulmonary vascular endothelial cells metabolise serotonin protecting the left heart chambers. | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Oxford University Press | |
dc.relation.ispartofpagefrom | 2326 | |
dc.relation.ispartofpageto | 2326 | |
dc.relation.ispartofissue | 34 | |
dc.relation.ispartofjournal | European Heart Journal | |
dc.relation.ispartofvolume | 36 | |
dc.subject.fieldofresearch | Cardiovascular medicine and haematology | |
dc.subject.fieldofresearch | Clinical sciences | |
dc.subject.fieldofresearchcode | 3201 | |
dc.subject.fieldofresearchcode | 3202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Cardiac & Cardiovascular Systems | |
dc.subject.keywords | Cardiovascular System & Cardiology | |
dc.title | Carcinoid heart disease | |
dc.type | Journal article | |
dcterms.bibliographicCitation | Dashwood, A; Rahman, A; Pavicic, M, Carcinoid heart disease, European Heart Journal, 2015, 36 (34), pp. 2326-2326 | |
dc.date.updated | 2020-06-22T12:13:41Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2015 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European Heart Journal following peer review. The definitive publisher-authenticated version Carcinoid heart disease, European Heart Journal, Volume 36, Issue 34, 7 September 2015, Page 2326 is available online at: 10.1093/eurheartj/ehv070 | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Dashwood, Alexander M. | |
gro.griffith.author | Rahman, Atifur | |