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dc.contributor.authorDashwood, Alexander
dc.contributor.authorRahman, Atifur
dc.contributor.authorPavicic, Matthew
dc.date.accessioned2020-06-23T00:57:44Z
dc.date.available2020-06-23T00:57:44Z
dc.date.issued2015
dc.identifier.issn0195-668X
dc.identifier.doi10.1093/eurheartj/ehv070
dc.identifier.urihttp://hdl.handle.net/10072/394793
dc.description.abstractA 72-year-old gentleman presented with right heart failure (RHF) from tricuspid insufficiency. He also noted episodes of diarrhoea and flushing. Echocardiogram showed severe tricuspid regurgitation (TR) with thickened tricuspid leaflets (Panel A). The subcostal view revealed a hepatic mass, which, following biopsy and evaluation of 5-hydroxytryptamine, was confirmed as metastatic carcinoid tumour (Panel B). Carcinoid heart disease (CHD), namely TR, is the initial presentation of carcinoid tumours in up to 20% of patients. Serotonin, by activating the 5-HT(2B) receptor, induces fibrous tissue deposition on the endocardial surface of valvular cusps and cardiac chambers. Pulmonary vascular endothelial cells metabolise serotonin protecting the left heart chambers.
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom2326
dc.relation.ispartofpageto2326
dc.relation.ispartofissue34
dc.relation.ispartofjournalEuropean Heart Journal
dc.relation.ispartofvolume36
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCardiac & Cardiovascular Systems
dc.subject.keywordsCardiovascular System & Cardiology
dc.titleCarcinoid heart disease
dc.typeJournal article
dcterms.bibliographicCitationDashwood, A; Rahman, A; Pavicic, M, Carcinoid heart disease, European Heart Journal, 2015, 36 (34), pp. 2326-2326
dc.date.updated2020-06-22T12:13:41Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2015 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European Heart Journal following peer review. The definitive publisher-authenticated version Carcinoid heart disease, European Heart Journal, Volume 36, Issue 34, 7 September 2015, Page 2326 is available online at: 10.1093/eurheartj/ehv070
gro.hasfulltextFull Text
gro.griffith.authorDashwood, Alexander M.
gro.griffith.authorRahman, Atifur


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