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dc.contributor.authorLui, Hayman
dc.contributor.authorVaquette, Cedryck
dc.contributor.authorDenbeigh, Janet M
dc.contributor.authorBindra, Randy
dc.contributor.authorKakar, Sanjeev
dc.contributor.authorvan Wijnen, Andre J
dc.date.accessioned2020-07-01T01:28:07Z
dc.date.available2020-07-01T01:28:07Z
dc.date.issued2020
dc.identifier.issn0736-0266
dc.identifier.doi10.1002/jor.24785
dc.identifier.urihttp://hdl.handle.net/10072/395039
dc.description.abstractScapholunate interosseous ligament tears are a common wrist injury in young and active patients that can lead to suboptimal outcomes after repair. This research aims to assess a multiphasic scaffold using 3D-printing for reconstruction of the dorsal scapholunate interosseous ligament. The scaffold was surgically implanted in vivo in the position of the native rabbit medial collateral ligament. Two branches of treatment were implemented in the study. In the first group, the rabbits (n=8) had the knee joint fixed in flexion for 4 weeks using 1.4mm K-wires prior to sample harvesting. The second group (n=8) had the rabbit knee joint immobilised for 4 weeks prior to K-wire removal and mobilisation for an additional 4 weeks prior to sample harvesting. Overall, samples were harvested at four week post-surgery (immobilised group) and eight weeks post-surgery (mobilised group). Mechanical tensile testing (n=5/group) and histology (n=3/group) of the constructs were conducted. Tissue integration and maturation was observed resulting in increased mechanical strength of the operated joint at 8 weeks (p<0.05). Bone and ligament tissues were regenerated in their respective compartments with structural and mechanical properties approaching those reported for the human dorsal SLIL ligament.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofjournalJournal of Orthopaedic Research
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4207
dc.subject.keywords3D-printing
dc.subject.keywordshand surgery
dc.subject.keywordsligament reconstruction
dc.subject.keywordstissue-engineering
dc.titleMultiphasic scaffold for scapholunate interosseous ligament reconstruction: a study in the rabbit knee
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationLui, H; Vaquette, C; Denbeigh, JM; Bindra, R; Kakar, S; van Wijnen, AJ, Multiphasic scaffold for scapholunate interosseous ligament reconstruction: a study in the rabbit knee, Journal of Orthopaedic Research, 2020
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2020-06-30T04:45:48Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2020 Orthopaedic Research Society. This is the peer reviewed version of the following article: Multiphasic scaffold for scapholunate interosseous ligament reconstruction: a study in the rabbit knee, Journal of Orthopaedic Research, 2020, which has been published in final form at https://doi.org/10.1002/jor.24785. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorLui, Hayman H.


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