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dc.contributor.authorVenkatesan, Sudhir
dc.contributor.authorMyles, Puja R
dc.contributor.authorBolton, Kirsty J
dc.contributor.authorMuthuri, Stella G
dc.contributor.authorAl Khuwaitir, Tarig
dc.contributor.authorAnovadiya, Ashish P
dc.contributor.authorAzziz-Baumgartner, Eduardo
dc.contributor.authorBajjou, Tahar
dc.contributor.authorBassetti, Matteo
dc.contributor.authorBeovic, Bojana
dc.contributor.authorBertisch, Barbara
dc.contributor.authorBonmarin, Isabelle
dc.contributor.authorBooy, Robert
dc.contributor.authorKeijzers, Gerben
dc.contributor.authoret al.
dc.date.accessioned2020-07-06T05:14:19Z
dc.date.available2020-07-06T05:14:19Z
dc.date.issued2020
dc.identifier.issn0022-1899
dc.identifier.doi10.1093/infdis/jiz152
dc.identifier.urihttp://hdl.handle.net/10072/395166
dc.description.abstractBackground: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. Results: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. Conclusions: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom356
dc.relation.ispartofpageto366
dc.relation.ispartofissue3
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume221
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsImmunology
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsMicrobiology
dc.titleNeuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationVenkatesan, et al., Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection, Journal of Infectious Diseases, 2020, 221 (3), pp. 356-366
dcterms.dateAccepted2019-05-16
dc.date.updated2020-07-06T01:47:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorKeijzers, Gerben


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