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dc.contributor.authorSteinmetz, Nicole F
dc.contributor.authorLim, Sierin
dc.contributor.authorSainsbury, Frank
dc.date.accessioned2020-07-09T01:58:49Z
dc.date.available2020-07-09T01:58:49Z
dc.date.issued2020
dc.identifier.issn2047-4830
dc.identifier.doi10.1039/d0bm00159g
dc.identifier.urihttp://hdl.handle.net/10072/395185
dc.description.abstractProtein cages (viral and non-viral) found in nature have evolved for a variety of purposes and are found in all kingdoms of life. The main functions of these nanoscale compartments are the protection and delivery of nucleic acids e.g. virus capsids, or the enrichment and sequestration of metabolons e.g. bacterial microcompartments. This review focuses on recent developments of protein cages for use in immunotherapy and therapeutic delivery. In doing so, we highlight the unique ways in which protein cages have informed on fundamental principles governing bio-nano interactions. With the enormous existing design space among naturally occurring protein cages, there is still much to learn from studying them as biomimetic particles.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofpagefrom2771
dc.relation.ispartofpageto2777
dc.relation.ispartofissue10
dc.relation.ispartofjournalBiomaterials Science
dc.relation.ispartofvolume8
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1004
dc.subject.keywordsScience & Technology
dc.subject.keywordsMaterials Science, Biomaterials
dc.subject.keywordsIN-SITU VACCINATION
dc.titleProtein cages and virus-like particles: from fundamental insight to biomimetic therapeutics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSteinmetz, NF; Lim, S; Sainsbury, F, Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics, Biomaterials Science, 2020, 8 (10), pp. 2771-2777
dc.date.updated2020-07-06T04:52:07Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2020 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorSainsbury, Frank


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