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dc.contributor.authorDe Oliveira, David MP
dc.contributor.authorEverest-Dass, Arun
dc.contributor.authorHartley-Tassell, Lauren
dc.contributor.authorDay, Christopher J
dc.contributor.authorIndraratna, Anuk
dc.contributor.authorBrouwer, Stephan
dc.contributor.authorCleary, Ailish
dc.contributor.authorKautto, Liisa
dc.contributor.authorGorman, Jody
dc.contributor.authorPacker, Nicolle H
dc.contributor.authorJennings, Michael P
dc.contributor.authorWalker, Mark J
dc.contributor.authorSanderson-Smith, Martina L
dc.date.accessioned2020-07-07T01:20:32Z
dc.date.available2020-07-07T01:20:32Z
dc.date.issued2019
dc.identifier.issn0892-6638
dc.identifier.doi10.1096/fj.201900559R
dc.identifier.urihttp://hdl.handle.net/10072/395216
dc.description.abstractColonization of the oropharynx is the initial step in Group A Streptococcus (GAS) pharyngeal infection. We have previously reported that the highly virulent M1T1 GAS clone attaches to oral epithelial cells via M1 protein interaction with blood group antigen carbohydrate structures. Here, we have identified that colonization of human oral epithelial cells by GAS serotypes M3 and M12 is mediated by human blood group antigens [ABO(H)] and Lewis (Le) antigen expression. Removal of linkage‐specific fucose, galactose, N‐acetylgalactosamine, and sialic acid modulated GAS colonization, dependent on host ABO(H) blood group and Le expression profile. Furthermore, N‐linked glycans from human salivary glycoproteins, when released and purified, were potent inhibitors of M1, M3, and M12 GAS colonization ex vivo . These data highlight the important role played by human protein glycosylation patterns in GAS attachment to oral epithelial cell surfaces.—De Oliveira, D. M. P., Everest‐Dass, A., Hartley‐Tassell, L., Day, C. J., Indraratna, A., Brouwer, S., Cleary, A., Kautto, L., Gorman, J., Packer, N. H., Jennings, M. P., Walker, M. J., Sanderson‐Smith, M. L. Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFederation of American Societies for Experimental Biology
dc.relation.ispartofpagefrom10808
dc.relation.ispartofpageto10818
dc.relation.ispartofissue10
dc.relation.ispartofjournalFASEB Journal
dc.relation.ispartofvolume33
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1143266
dc.relation.grantIDAPP1143266
dc.relation.fundersNHMRC
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1116
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordsBiology
dc.subject.keywordsCell Biology
dc.titleHuman glycan expression patterns influence Group A streptococcal colonization of epithelial cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDe Oliveira, DMP; Everest-Dass, A; Hartley-Tassell, L; Day, CJ; Indraratna, A; Brouwer, S; Cleary, A; Kautto, L; Gorman, J; Packer, NH; Jennings, MP; Walker, MJ; Sanderson-Smith, ML, Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells, FASEB Journal, 2019, 33 (10), pp. 10808-10818
dc.date.updated2020-07-07T01:19:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorEverest-Dass, Arun
gro.griffith.authorDay, Christopher J.
gro.griffith.authorHartley-Tassell, Lauren E.
gro.griffith.authorJennings, Michael P.
gro.griffith.authorPacker, Nicki


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