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dc.contributor.authorSemchenko, Evgeny A
dc.contributor.authorMubaiwa, Tsitsi D
dc.contributor.authorDay, Christopher J
dc.contributor.authorSeib, Kate L
dc.date.accessioned2020-07-07T01:31:01Z
dc.date.available2020-07-07T01:31:01Z
dc.date.issued2020
dc.identifier.issn0022-1899
dc.identifier.doi10.1093/infdis/jiz628
dc.identifier.urihttp://hdl.handle.net/10072/395218
dc.description.abstractThe sexually transmitted infection gonorrhoea is on the rise worldwide and an increased understanding of the mechanisms of colonization and pathogenesis of Neisseria gonorrhoeae is required to aid development of new treatment and prevention strategies. In the current study, we investigate the neisserial heparin-binding antigen (NHBA) of N. gonorrhoeae and confirm its role in binding to several glycans, including heparin, and identify interactions of NHBA with both gonococcal and host cells. Furthermore, we report that a gonococcal nhba mutant displays decreased cell aggregation and microcolony formation, as well as reduced survival in human serum and reduced adherence to human cervical and urethral epithelial cells, relative to the wild-type strain. These data indicate that the gonococcal NHBA contributes to several aspects of the colonization and survival of N. gonorrhoeae and may be a target for new antimicrobial or vaccines.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofpagefrom1612
dc.relation.ispartofpageto1622
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume221
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsImmunology
dc.subject.keywordsInfectious Diseases
dc.subject.keywordsMicrobiology
dc.titleRole of the Gonococcal Neisserial Heparin Binding Antigen in Microcolony Formation, and Serum Resistance and Adherence to Epithelial Cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSemchenko, EA; Mubaiwa, TD; Day, CJ; Seib, KL, Role of the Gonococcal Neisserial Heparin Binding Antigen in Microcolony Formation, and Serum Resistance and Adherence to Epithelial Cells, Journal of Infectious Diseases, 2020, 221 (10), pp. 1612-1622
dcterms.dateAccepted2019-11-26
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-07-07T01:28:50Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence, which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Supplementary data
gro.hasfulltextFull Text
gro.griffith.authorSeib, Kate
gro.griffith.authorSemchenko, Evgeny
gro.griffith.authorMubaiwa, Tsitsi D.
gro.griffith.authorDay, Christopher J.


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