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dc.contributor.authorZhou, Ying
dc.contributor.authorLittle, Peter J
dc.contributor.authorTa, Hang T
dc.contributor.authorXu, Suowen
dc.contributor.authorKamato, Danielle
dc.date.accessioned2020-07-09T02:17:29Z
dc.date.available2020-07-09T02:17:29Z
dc.date.issued2019
dc.identifier.issn0163-7258
dc.identifier.doi10.1016/j.pharmthera.2019.107404
dc.identifier.urihttp://hdl.handle.net/10072/395266
dc.description.abstractLysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and atherosclerosis. There have recently been considerable advances in GPCR signaling especially recognition of the extended role for GPCR transactivation of tyrosine and serine/threonine kinase growth factor receptors. This review covers LPA signaling pathways in the light of new information. The use of transgenic and gene knockout animals, gene manipulated cells, pharmacological LPA receptor agonists and antagonists have provided many insights into the biological significance of LPA and individual LPA receptors in the progression of atherosclerosis and vascular diseases. This review provides a comprehensive presentation of LPA with the highlight of the distinct role of its receptors in cell and animal models that relate to atherosclerosis and vascular diseases, and therefore provides new opportunities to reduce the burden of cardiovascular diseases. The recent drug development strategies that target LPA signaling pathways are also included in this review.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofjournalPharmacology & Therapeutics
dc.relation.ispartofvolume204
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode1115
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPharmacology & Pharmacy
dc.subject.keywordsLysophosphatidic acid
dc.subject.keywordsG-protein coupled receptors
dc.titleLysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationZhou, Y; Little, PJ; Ta, HT; Xu, S; Kamato, D, Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease, Pharmacology & Therapeutics, 2019, 204
dcterms.dateAccepted2019-08-21
dc.date.updated2020-07-09T02:14:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorTa, Hang


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