Show simple item record

dc.contributor.authorYusof, Nur Nazifah Mohd
dc.contributor.authorMcCann, Andrew
dc.contributor.authorLittle, Peter J
dc.contributor.authorTa, Hang T
dc.date.accessioned2020-07-09T02:24:22Z
dc.date.available2020-07-09T02:24:22Z
dc.date.issued2019
dc.identifier.issn0049-3848
dc.identifier.doi10.1016/j.thromres.2019.03.009
dc.identifier.urihttp://hdl.handle.net/10072/395268
dc.description.abstractThrombosis is the localized clotting of blood that can occur in both the arterial and venous circulation. It is a key factor in the pathogenesis of acute coronary syndrome, myocardial infarction and stroke and the primary cause of deep vein thrombosis and pulmonary embolism. Rapid and accurate diagnosis of thrombotic episodes is crucial in reducing the morbidity and potential mortality associated with arterial and venous thrombotic disorders by allowing early targeted therapeutic interventions. From a clinical perspective the ability to accurately assess the age and composition of thrombus is highly desirable given that anticoagulation and, in particular, fibrinolytic therapies are more effective in treating acute rather than chronic thrombosis. While there are no imaging tests used in routine clinical practice that can reliably determine the age of thrombus and differentiate between acute and chronic thrombosis there are several emerging non-invasive techniques that can provide an indication of the age of a thrombus depending on its location in the body. Examples of techniques developed for venous thrombosis include Doppler imaging with venous duplex ultrasonography, ultrasound B-mode imaging integrated with IER (intrinsic mode functions-based echogenicity ratio), elastography, scintigraphy imaging with 99m Tc-recombinant tissue plasminogen activator ( 99m Tc-rt-PA), and magnetic resonance direct thrombus imaging (MDRTI). Magnetic resonance imaging (MRI) has been used to noninvasively detect and differentiate acute and chronic arterial and venous thrombosis. These methods have limitations that need further investigation to enable cost-effective and clinically relevant treatment practices to be established in the future. This review will discuss the difference between acute and chronic thrombosis and the role of non-invasive imaging techniques in discriminating between the two.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom161
dc.relation.ispartofpageto171
dc.relation.ispartofjournalThrombosis Research
dc.relation.ispartofvolume177
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsHematology
dc.subject.keywordsPeripheral Vascular Disease
dc.subject.keywordsCardiovascular System & Cardiology
dc.titleNon-invasive imaging techniques for the differentiation of acute and chronic thrombosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYusof, NNM; McCann, A; Little, PJ; Ta, HT, Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis, Thrombosis Research, 2019, 177, pp. 161-171
dcterms.dateAccepted2019-03-13
dc.date.updated2020-07-09T02:22:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorTa, Hang


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record