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dc.contributor.authorGuo, LC
dc.contributor.authorLiu, T
dc.contributor.authorYang, Y
dc.contributor.authorYu, S
dc.contributor.authorGao, Y
dc.contributor.authorHuang, W
dc.contributor.authorXiao, J
dc.contributor.authorMa, W
dc.contributor.authorRutherford, S
dc.contributor.authorZhang, Y
dc.date.accessioned2020-07-15T02:05:26Z
dc.date.available2020-07-15T02:05:26Z
dc.date.issued2020
dc.identifier.issn0048-9697
dc.identifier.doi10.1016/j.scitotenv.2020.140597
dc.identifier.urihttp://hdl.handle.net/10072/395414
dc.description.abstractPolychlorinated biphenyls (PCBs) and halogen flame retardants (HFRs) are major pollutants in e-waste recycling area. High internal exposure levels of PCBs and HFRs are harmful to human thyroid hormone (TH) equilibrium. To examine their disrupting effects on TH, we conducted a study on children (n = 114) of an e-waste recycling and a control area in South China. Concentrations of PCBs, HFRs, and TH levels were determined in serum samples. TH related proteins and their corresponding gene were also monitored as markers of such disruption. Levels of these chemicals in the exposed group were much greater than those in the control group. Results of the linear regression and generalized additive model indicated the presence of close relationships between the internal exposure levels and the responses of TH related proteins, gene expression. More extensive exposure concentrations of these chemicals led to higher expression of iodothyronine deiodinase I and decreased the concentrations of thyroid-stimulating hormone, expression of TH receptor α, indicating the exertion of discrepant and even contrary influences on equilibrium of TH, and a compensation of these mechanisms may kept the homeostasis of TH. These results for children warrant further investigation on the health risks of PCBs and HFRs exposure in e-waste area.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier BV
dc.relation.ispartofjournalScience of the Total Environment
dc.relation.ispartofvolume742
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsGene expression
dc.subject.keywordsHomeostasis
dc.subject.keywordsThyroid hormone disruption
dc.titleChanges in thyroid hormone related proteins and gene expression induced by polychlorinated biphenyls and halogen flame retardants exposure of children in a Chinese e-waste recycling area
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGuo, LC; Liu, T; Yang, Y; Yu, S; Gao, Y; Huang, W; Xiao, J; Ma, W; Rutherford, S; Zhang, Y, Changes in thyroid hormone related proteins and gene expression induced by polychlorinated biphenyls and halogen flame retardants exposure of children in a Chinese e-waste recycling area, Science of the Total Environment, 2020, 742
dcterms.dateAccepted2020-06-27
dc.date.updated2020-07-15T01:59:16Z
gro.hasfulltextNo Full Text
gro.griffith.authorRutherford, Shannon


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