dc.contributor.author | Xie, Y | |
dc.contributor.author | Jun, D | |
dc.contributor.author | Thomas, L | |
dc.contributor.author | Coombes, BK | |
dc.contributor.author | Johnston, V | |
dc.date.accessioned | 2020-07-19T21:59:08Z | |
dc.date.available | 2020-07-19T21:59:08Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1526-5900 | |
dc.identifier.doi | 10.1016/j.jpain.2020.02.007 | |
dc.identifier.uri | http://hdl.handle.net/10072/395609 | |
dc.description.abstract | This systematic review and meta-analysis examined the evidence for altered central pain processing in people with non-traumatic neck pain and the relationship between central pain processing, demographics and pain-related characteristics. Case-control studies reporting measures of altered central pain processing using quantitative sensory testing were reviewed. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) between people with non-traumatic neck pain and controls were calculated. Meta-analysis was performed using random-effects models when appropriate. Associations between SMDs with demographics and pain-related characteristics were explored on a study level using meta-regression. Twenty-six studies were eligible with 25 included for meta-analysis. Meta-analysis demonstrated mechanical hyperalgesia at remote non-painful sites in the full sample [sample size (n)=1305, SMD=-0.68] and in the subgroup with moderate/severe disability [n=165, SMD=-0.86] (moderate-quality evidence). Meta-regression indicated that remote mechanical hyperalgesia was negatively associated with age (R2=25.4%, P=0.031). Very-low- to low-quality evidence of remote cold and heat hyperalgesia and dysfunctional conditioned pain modulation were identified. This review suggests that altered central pain processing is present in people with non-traumatic neck pain and may be associated with disability levels and age. Perspective: This review found moderate-quality evidence of mechanical hyperalgesia at remote non-painful sites in patients with non-traumatic neck pain compared to controls, indicating altered central pain processing. However, more studies are needed to confirm findings from dynamic quantitative sensory testing. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofjournal | Journal of Pain | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Psychology | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 52 | |
dc.subject.keywords | central sensitization | |
dc.subject.keywords | idiopathic neck pain | |
dc.subject.keywords | meta-analysis | |
dc.subject.keywords | nonspecific neck pain | |
dc.subject.keywords | quantitative sensory testing | |
dc.title | Comparing central pain processing in individuals with non-traumatic neck pain and healthy individuals: a systematic review and meta-analysis. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Xie, Y; Jun, D; Thomas, L; Coombes, B; Johnston, V, Comparing central pain processing in individuals with non-traumatic neck pain and healthy individuals: a systematic review and meta-analysis., Journal of Pain, 2020 | |
dcterms.dateAccepted | 2020-02-23 | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.date.updated | 2020-07-19T02:37:46Z | |
dc.description.version | Accepted Manuscript (AM) | |
gro.description.notepublic | This publication has been entered in Griffith Research Online as an advanced online version. | |
gro.rights.copyright | © 2020 American Pain Society. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Coombes, Brooke K. | |