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dc.contributor.authorXie, Y
dc.contributor.authorJun, D
dc.contributor.authorThomas, L
dc.contributor.authorCoombes, BK
dc.contributor.authorJohnston, V
dc.date.accessioned2020-07-19T21:59:08Z
dc.date.available2020-07-19T21:59:08Z
dc.date.issued2020
dc.identifier.issn1526-5900
dc.identifier.doi10.1016/j.jpain.2020.02.007
dc.identifier.urihttp://hdl.handle.net/10072/395609
dc.description.abstractThis systematic review and meta-analysis examined the evidence for altered central pain processing in people with non-traumatic neck pain and the relationship between central pain processing, demographics and pain-related characteristics. Case-control studies reporting measures of altered central pain processing using quantitative sensory testing were reviewed. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) between people with non-traumatic neck pain and controls were calculated. Meta-analysis was performed using random-effects models when appropriate. Associations between SMDs with demographics and pain-related characteristics were explored on a study level using meta-regression. Twenty-six studies were eligible with 25 included for meta-analysis. Meta-analysis demonstrated mechanical hyperalgesia at remote non-painful sites in the full sample [sample size (n)=1305, SMD=-0.68] and in the subgroup with moderate/severe disability [n=165, SMD=-0.86] (moderate-quality evidence). Meta-regression indicated that remote mechanical hyperalgesia was negatively associated with age (R2=25.4%, P=0.031). Very-low- to low-quality evidence of remote cold and heat hyperalgesia and dysfunctional conditioned pain modulation were identified. This review suggests that altered central pain processing is present in people with non-traumatic neck pain and may be associated with disability levels and age. Perspective: This review found moderate-quality evidence of mechanical hyperalgesia at remote non-painful sites in patients with non-traumatic neck pain compared to controls, indicating altered central pain processing. However, more studies are needed to confirm findings from dynamic quantitative sensory testing.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofjournalJournal of Pain
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.subject.keywordscentral sensitization
dc.subject.keywordsidiopathic neck pain
dc.subject.keywordsmeta-analysis
dc.subject.keywordsnonspecific neck pain
dc.subject.keywordsquantitative sensory testing
dc.titleComparing central pain processing in individuals with non-traumatic neck pain and healthy individuals: a systematic review and meta-analysis.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationXie, Y; Jun, D; Thomas, L; Coombes, B; Johnston, V, Comparing central pain processing in individuals with non-traumatic neck pain and healthy individuals: a systematic review and meta-analysis., Journal of Pain, 2020
dcterms.dateAccepted2020-02-23
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2020-07-19T02:37:46Z
dc.description.versionAccepted Manuscript (AM)
gro.description.notepublicThis publication has been entered in Griffith Research Online as an advanced online version.
gro.rights.copyright© 2020 American Pain Society. Published by Elsevier Ltd. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCoombes, Brooke K.


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