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  • Fatigue numeric rating scale validity, discrimination and responder definition in patients with psoriatic arthritis

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    Author(s)
    Gladman, Dafna
    Nash, Peter
    Goto, Hitoshi
    Birt, Julie A
    Lin, Chen-Yen
    Orbai, Ana-Maria
    Kvien, Tore K
    Griffith University Author(s)
    Nash, Peter
    Year published
    2020
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    Abstract
    Objectives This study assessed the psychometric properties of the fatigue numeric rating scale (NRS) and sought to establish values for clinically meaningful change (responder definition). Methods Using disease-specific clinician-reported and patient-reported data from two randomised clinical trials of patients with psoriatic arthritis (PsA), the fatigue NRS was evaluated for test-retest reliability, construct validity and responsiveness. A responder definition was also explored using anchor-based and distribution-based methods. Results Test-retest reliability analyses supported the reproducibility of the fatigue NRS in ...
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    Objectives This study assessed the psychometric properties of the fatigue numeric rating scale (NRS) and sought to establish values for clinically meaningful change (responder definition). Methods Using disease-specific clinician-reported and patient-reported data from two randomised clinical trials of patients with psoriatic arthritis (PsA), the fatigue NRS was evaluated for test-retest reliability, construct validity and responsiveness. A responder definition was also explored using anchor-based and distribution-based methods. Results Test-retest reliability analyses supported the reproducibility of the fatigue NRS in patients with PsA (intraclass correlation coefficient=0.829). Mean (SD) values at baseline and week 2 were 5.7 (2.2) and 5.7 (2.4), respectively. Supporting construct validity of the fatigue NRS, moderate-to-large correlations with other assessments measuring similar concepts as measured by Sackett's conventions were demonstrated. Fatigue severity was reduced when the underlying disease activity was improved and reductions remained consistent at week 12 and 24. A 3-point improvement was identified as being optimal for demonstrating a level of clinically meaningful improvement in fatigue NRS after 12-24 weeks of treatment. Conclusions Fatigue NRS is a valid and responsive patient-reported outcome instrument for use in patients with PsA. The established psychometric properties from this study support the use of fatigue NRS in clinical trials and in routine clinical practice. Robust validation of reliability for use in routine clinical practice in treating patients with active PsA in less active disease states and other more diverse ethnic groups is needed.
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    Journal Title
    RMD Open
    Volume
    6
    Issue
    1
    DOI
    https://doi.org/10.1136/rmdopen-2019-000928
    Copyright Statement
    © Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
    Subject
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Rheumatology
    HEALTH-ASSESSMENT QUESTIONNAIRE
    DISEASE-ACTIVITY
    Publication URI
    http://hdl.handle.net/10072/395639
    Collection
    • Journal articles

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