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dc.contributor.authorBaade, Peter D
dc.contributor.authorWhiteman, David C
dc.contributor.authorJanda, Monika
dc.contributor.authorCust, Anne E
dc.contributor.authorNeale, Rachel E
dc.contributor.authorSmithers, Bernard Mark
dc.contributor.authorGreen, Adele C
dc.contributor.authorKhosrotehrani, Kiarash
dc.contributor.authorMar, Victoria
dc.contributor.authorSoyer, H Peter
dc.contributor.authorAitken, Joanne F
dc.date.accessioned2020-07-20T23:44:31Z
dc.date.available2020-07-20T23:44:31Z
dc.date.issued2020
dc.identifier.issn0020-7136
dc.identifier.doi10.1002/ijc.32930
dc.identifier.urihttp://hdl.handle.net/10072/395644
dc.description.abstractThere is little long-term follow-up information about how the number of melanoma deaths and case fatality vary over time according to the measured thickness of melanoma at diagnosis. This population-based longitudinal cohort study examines patterns and trends in case fatality among 44,531 people in Queensland (Australia) diagnosed with a single invasive melanoma (International Classification of Diseases for Oncology, third revision [ICD-O-3], C44, Morphology 872–879) between 1987 and 2011, including 11,883 diagnosed between 1987 and 1996, with up to 20 years follow-up (to December 2016). The 20-year case fatality increased by thickness, with the percentage of melanoma deaths within 20 years of diagnosis being up to 4.8% for melanomas with measured thickness <0.80 mm, 10.6% for tumors 0.8 to <1.0 mm and generally more than 30% for melanomas measuring 3 mm and more. For melanomas <1.0 mm, most deaths occurred between 5 and 20 years after diagnosis, whereas for thicker melanomas the reverse was true with most deaths occurring within the first 5 years. Five-year case fatality decreased over successive calendar time periods for melanomas <1.0 mm, but not for melanomas ≥1.0 mm. These findings demonstrate that the time course for fatal melanomas varies markedly according to tumor thickness at diagnosis. Improved understanding of the patient factors and characteristics of melanomas, in addition to tumor thickness, which increase the likelihood of progression, is needed to guide clinical diagnosis, communication with patients and ongoing surveillance pathways of patients with potentially fatal lesions.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofpagefrom1391
dc.relation.ispartofpageto1396
dc.relation.ispartofissue5
dc.relation.ispartofjournalInternational Journal of Cancer
dc.relation.ispartofvolume147
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsHIGH-RISK
dc.subject.keywordsINTERVENTION
dc.titleLong-term deaths from melanoma according to tumor thickness at diagnosis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBaade, PD; Whiteman, DC; Janda, M; Cust, AE; Neale, RE; Smithers, BM; Green, AC; Khosrotehrani, K; Mar, V; Soyer, HP; Aitken, JF, Long-term deaths from melanoma according to tumor thickness at diagnosis, International Journal of Cancer, 2020, 147 (5), pp. 1391-1396
dcterms.dateAccepted2020-02-10
dc.date.updated2020-07-20T23:41:41Z
gro.hasfulltextNo Full Text
gro.griffith.authorBaade, Peter D.
gro.griffith.authorAitken, Joanne


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