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dc.contributor.authorPopa-Wagner, A
dc.contributor.authorPetcu, EB
dc.contributor.authorCapitanescu, B
dc.contributor.authorHermann, DM
dc.contributor.authorRadu, E
dc.contributor.authorGresita, A
dc.date.accessioned2020-07-21T01:33:02Z
dc.date.available2020-07-21T01:33:02Z
dc.date.issued2020
dc.identifier.issn0047-6374
dc.identifier.doi10.1016/j.mad.2020.111312
dc.identifier.urihttp://hdl.handle.net/10072/395659
dc.description.abstractAge is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and behavioral adaptation to stroke risk factors and comorbidities was successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravates the outcome after cerebral ischemia. However, due to the increased in number of elderly, the incidence of stroke has increased again paralleled by an increase in the number of stroke survivors, many with severe disabilities, that has led to an increased economic and social burden in society. Animal models of stroke often ignore age and comorbidities frequently associated with senescence. This might explain why drugs working nicely in animal models fail to show efficacy in stroke survivors. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of stroke therapies in an appropriate animal stroke model. Therefore, in this review, we make parallels between animal models of stroke und clinical data and summarize the impact of ageing and age-related comorbidities on stroke outcome.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom111312
dc.relation.ispartofjournalMechanisms of Ageing and Development
dc.relation.ispartofvolume190
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsAgeing
dc.subject.keywordsCerebral ischemia
dc.subject.keywordsNeuroinflammation
dc.subject.keywordsRecovery
dc.subject.keywordsRisk factors
dc.titleAgeing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPopa-Wagner, A; Petcu, EB; Capitanescu, B; Hermann, DM; Radu, E; Gresita, A, Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic, Mechanisms of Ageing and Development, 2020, 190, pp. 111312
dcterms.dateAccepted2020-07-06
dc.date.updated2020-07-21T01:05:11Z
gro.hasfulltextNo Full Text
gro.griffith.authorPetcu, Eugen B.
gro.griffith.authorPopa-Wagner, Aurel


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