dc.contributor.author | Maeda, Gasper | |
dc.contributor.author | Munissi, Joan JE | |
dc.contributor.author | Lindblad, Sofia | |
dc.contributor.author | Duffy, Sandra | |
dc.contributor.author | Pelletier, Jerry | |
dc.contributor.author | Avery, Vicky M | |
dc.contributor.author | Nyandoro, Stephen S | |
dc.contributor.author | Erdelyi, Mate | |
dc.date.accessioned | 2020-07-24T05:42:27Z | |
dc.date.available | 2020-07-24T05:42:27Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00721 | |
dc.identifier.uri | http://hdl.handle.net/10072/395813 | |
dc.description.abstract | A new meroisoprenoid (1), two heptenolides (2 and 3), two C-benzylated flavonoids (4 and 5), and 11 known compounds (6-16) were isolated from leaf, stem bark, and root bark extracts of Sphaerocoryne gracilis ssp. gracilis by chromatographic separation. The structures of the new metabolites 1-5 were established by NMR, IR, and UV spectroscopic and mass spectrometric data analysis. (Z)-Sphaerodiol (7), (Z)-acetylmelodorinol (8), 7-hydroxy-6-hydromelodienone (10), and dichamanetin (15) inhibited the proliferation of Plasmodium falciparum (3D7, Dd2) with IC50 values of 1.4-10.5 μM, although these compounds also showed cytotoxicity against human embryonic kidney HEK-293 cells. None of the compounds exhibited significant disruption in protein translation when assayed in vitro. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.ispartofpagefrom | 316 | |
dc.relation.ispartofpageto | 322 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 83 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Plant Sciences | |
dc.subject.keywords | Chemistry, Medicinal | |
dc.subject.keywords | Pharmacology & Pharmacy | |
dc.title | A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Maeda, G; Munissi, JJE; Lindblad, S; Duffy, S; Pelletier, J; Avery, VM; Nyandoro, SS; Erdelyi, M, A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis, Journal of Natural Products, 2020, 83 (2), pp. 316-322 | |
dc.date.updated | 2020-07-24T05:40:25Z | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Duffy, Sandra | |
gro.griffith.author | Avery, Vicky M. | |