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dc.contributor.authorMaeda, Gasper
dc.contributor.authorMunissi, Joan JE
dc.contributor.authorLindblad, Sofia
dc.contributor.authorDuffy, Sandra
dc.contributor.authorPelletier, Jerry
dc.contributor.authorAvery, Vicky M
dc.contributor.authorNyandoro, Stephen S
dc.contributor.authorErdelyi, Mate
dc.date.accessioned2020-07-24T05:42:27Z
dc.date.available2020-07-24T05:42:27Z
dc.date.issued2020
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.9b00721
dc.identifier.urihttp://hdl.handle.net/10072/395813
dc.description.abstractA new meroisoprenoid (1), two heptenolides (2 and 3), two C-benzylated flavonoids (4 and 5), and 11 known compounds (6-16) were isolated from leaf, stem bark, and root bark extracts of Sphaerocoryne gracilis ssp. gracilis by chromatographic separation. The structures of the new metabolites 1-5 were established by NMR, IR, and UV spectroscopic and mass spectrometric data analysis. (Z)-Sphaerodiol (7), (Z)-acetylmelodorinol (8), 7-hydroxy-6-hydromelodienone (10), and dichamanetin (15) inhibited the proliferation of Plasmodium falciparum (3D7, Dd2) with IC50 values of 1.4-10.5 μM, although these compounds also showed cytotoxicity against human embryonic kidney HEK-293 cells. None of the compounds exhibited significant disruption in protein translation when assayed in vitro.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofpagefrom316
dc.relation.ispartofpageto322
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume83
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPlant Sciences
dc.subject.keywordsChemistry, Medicinal
dc.subject.keywordsPharmacology & Pharmacy
dc.titleA Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMaeda, G; Munissi, JJE; Lindblad, S; Duffy, S; Pelletier, J; Avery, VM; Nyandoro, SS; Erdelyi, M, A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis, Journal of Natural Products, 2020, 83 (2), pp. 316-322
dc.date.updated2020-07-24T05:40:25Z
gro.hasfulltextNo Full Text
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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