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dc.contributor.authorBegum, S
dc.contributor.authorMunissi, JJE
dc.contributor.authorBuriyo, AS
dc.contributor.authorMakangara, JJ
dc.contributor.authorLucantoni, L
dc.contributor.authorAvery, VM
dc.contributor.authorErdelyi, M
dc.contributor.authorNyandoro, SS
dc.date.accessioned2020-07-24T05:58:02Z
dc.date.available2020-07-24T05:58:02Z
dc.date.issued2020
dc.identifier.issn2231-1866
dc.identifier.doi10.1080/22311866.2020.1770125
dc.identifier.urihttp://hdl.handle.net/10072/395817
dc.description.abstractThis paper reports on the evaluation of antiplasmodial, antimicrobial and cytotoxic activities of extracts from eleven plant species traditionally used by some Tanzanian coastal communities for treatment of malaria, microbial infections and related ailments. Crude extracts from selected plant species namely Acacia zanzibarica, Danais xanthorrhoea, Diospyros loureiriana ssp. rufescens, Erythrina sacleuxii, Newtonia paucijuga, Pentas lanceolata, Scorodophloeus fischeri, Stuhlmannia moavi, Tarenna pavettoides, Tessmannia burttii and Toussaintia orientalis growing in Tanzania were investigated using an imaging-based assay (antiplasmodial), well diffusion and microplate dilution methods (antimicrobial) and human embryonic kidney cells (HEK 293) and brine shrimp larvae assays (toxicity). The extracts exhibited activities of varying potencies and cytotoxicity with IC50 values ranging from 0.45 ± 0.09 to 75.70 ± 24.19 μg/mL against Plasmodium falciparum (3D7 strain), MIC ranging from 0.25 to 2.0 mg/mL (against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Cryptococcus neoformans), LC50 ranging from 0.75 to 1000 μg/mL against brine shrimp larvae (Artemia salina) and IC50 ranging from 4.02 ± 1.05 to more than 289 μg/mL against HEK 293 cells. The observed bioactivities of some of the investigated plant extracts validate their ethnomedicinal use and are indicative of the presence of bioactive ingredients for further phytochemical investigations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherInforma UK Limited
dc.relation.ispartofpagefrom165
dc.relation.ispartofpageto176
dc.relation.ispartofissue2
dc.relation.ispartofjournalJournal of Biologically Active Products from Nature
dc.relation.ispartofvolume10
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode31
dc.titleAntiplasmodial, Antimicrobial and Cytotoxic Activities of Extracts from Selected Medicinal Plants Growing in Tanzania
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBegum, S; Munissi, JJE; Buriyo, AS; Makangara, JJ; Lucantoni, L; Avery, VM; Erdelyi, M; Nyandoro, SS, Antiplasmodial, Antimicrobial and Cytotoxic Activities of Extracts from Selected Medicinal Plants Growing in Tanzania, Journal of Biologically Active Products from Nature, 2020, 10 (2), pp. 165-176
dc.date.updated2020-07-24T05:57:21Z
gro.hasfulltextNo Full Text
gro.griffith.authorAvery, Vicky M.


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