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dc.contributor.authorStewart, Glenn M
dc.contributor.authorWheatley-Guy, Courtney M
dc.contributor.authorMorris, Norman R
dc.contributor.authorCoffman, Kirsten E
dc.contributor.authorStepanek, Jan
dc.contributor.authorCarlson, Alex R
dc.contributor.authorIssa, Amine
dc.contributor.authorSchmidt, Michael A
dc.contributor.authorJohnson, Bruce D
dc.date.accessioned2020-07-24T06:24:11Z
dc.date.available2020-07-24T06:24:11Z
dc.date.issued2020
dc.identifier.issn1439-6319
dc.identifier.doi10.1007/s00421-020-04319-3
dc.identifier.urihttp://hdl.handle.net/10072/395821
dc.description.abstractIntroduction: High-altitude ascent induces left (LV) and right (RV) ventricular adaptations secondary to hypoxia-related hemodynamic and myocardial alterations. Since cardiopulmonary decrements observed with aging (e.g., decreased LV compliance and increased pulmonary vascular resistance) may limit cardiac plasticity, this study examined myocardial adaptability throughout an 11 day sojourn to 5893 m in young and older-aged trekkers. Methods and results: Echocardiography was performed on 14 young (8 men; 32 ± 5 years) and 13 older-aged (8 men; 59 ± 5 years) subjects on non-trekking days (Day 0: 880 m; Day 3: 3100 m; Day 8: 4800 m; Day 12/post-climb: 880 m). RV systolic pressure (mmHg) was systematically higher in older-aged subjects (p < 0.01) with similar progressive increases observed during ascent for young and older subjects, respectively (Day 0: 18 ± 1 vs 20 ± 2; Day 3: 25 ± 2 vs 29 ± 3; Day 8: 30 ± 2 vs 35 ± 2). Estimates of LV filling pressure (E/E′) were systematically higher in older subjects (p < 0.01) with similar progressive decreases observed during ascent for young and older-aged subjects, respectively (Day 0: 5.6 ± 0.3 vs 6.7 ± 0.5; Day 3: 5.1 ± 0.2 vs 6.1 ± 0.3; Day 8: 4.7 ± 0.3 vs 5.4 ± 0.3). Overall, RV end-diastolic and end-systolic area increased at altitude (p < 0.01), while LV end-diastolic and end-systolic volume decreased (p < 0.01). However, all RV and LV morphological measures were similar on Day 3 and Day 8 (p > 0.05), and returned to baseline post-climb (p > 0.05). Excluding mild LV dilatation in some older-aged trekkers on Day 8/Day 12 (p < 0.01), altitude-induced morphological and functional adaptations were similar for all trekkers (p > 0.05). Conclusion: Altitude-induced myocardial adaptations are chamber specific, secondary to RV and LV hemodynamic alterations. Despite progressive hemodynamic alterations during ascent, morphological and functional cardiac perturbations plateaued, suggesting rapid myocardial adaptation which was mostly comparable in young and older-aged individuals.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofpagefrom799
dc.relation.ispartofpageto809
dc.relation.ispartofissue4
dc.relation.ispartofjournalEuropean Journal of Applied Physiology
dc.relation.ispartofvolume120
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchcode1106
dc.subject.keywordsAging
dc.subject.keywordsCardiac function
dc.subject.keywordsEchocardiography
dc.subject.keywordsExpedition
dc.subject.keywordsHigh altitude
dc.titleMyocardial adaptability in young and older-aged sea-level habitants sojourning at Mt Kilimanjaro: are cardiac compensatory limits reached in older trekkers?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationStewart, GM; Wheatley-Guy, CM; Morris, NR; Coffman, KE; Stepanek, J; Carlson, AR; Issa, A; Schmidt, MA; Johnson, BD, Myocardial adaptability in young and older-aged sea-level habitants sojourning at Mt Kilimanjaro: are cardiac compensatory limits reached in older trekkers?, European Journal of Applied Physiology, 2020, 120 (4), pp. 799-809
dcterms.dateAccepted2020-02-07
dc.date.updated2020-07-24T06:23:09Z
gro.hasfulltextNo Full Text
gro.griffith.authorMorris, Norman
gro.griffith.authorStewart, Glenn


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