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dc.contributor.authorGordon, CA
dc.contributor.authorKrause, L
dc.contributor.authorMcManus, DP
dc.contributor.authorMorrison, M
dc.contributor.authorWeerakoon, KG
dc.contributor.authorConnor, MC
dc.contributor.authorOlveda, RM
dc.contributor.authorRoss, AG
dc.contributor.authorGobert, GN
dc.date.accessioned2020-07-24T06:31:14Z
dc.date.available2020-07-24T06:31:14Z
dc.date.issued2020
dc.identifier.issn0020-7519
dc.identifier.doi10.1016/j.ijpara.2019.12.008
dc.identifier.urihttp://hdl.handle.net/10072/395823
dc.description.abstractPolyparasitism, involving soil-transmitted helminths. and Schistosoma blood flukes, is common in low to middle income countries. These helminths impact on the gut environment and can cause changes to the gut microbiome composition. Here we examined the gut microbiome in individuals with polyparasitism from two human cohorts in the Philippines utilising DNA sequencing-based profiling. Multiple helminth species infections were high with 70.3% of study participants harbouring at least two parasite species, and 16% harbouring at least five species. Increased numbers of helminth co-infections, in particular with the gut-resident soil-transmitted helminths, were significantly associated with increased bacterial diversity; however no significant parasite-gut microbiome associations were evident for individuals infected only with Schistosoma japonicum. In general, a healthy gut is associated with high bacterial diversity, which in these human cohorts may be the result of helminth-mediated immune modulation, or due to changes in the gut environment caused by these parasitic helminths.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom217
dc.relation.ispartofpageto225
dc.relation.ispartofissue3
dc.relation.ispartofjournalInternational Journal for Parasitology
dc.relation.ispartofvolume50
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3009
dc.subject.keywordsAncylostoma
dc.subject.keywordsAscaris
dc.subject.keywordsGut microbiome
dc.subject.keywordsHookworm
dc.subject.keywordsSchistosoma
dc.titleHelminths, polyparasitism, and the gut microbiome in the Philippines
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationGordon, CA; Krause, L; McManus, DP; Morrison, M; Weerakoon, KG; Connor, MC; Olveda, RM; Ross, AG; Gobert, GN, Helminths, polyparasitism, and the gut microbiome in the Philippines, International Journal for Parasitology, 2020, 50 (3), pp. 217-225
dcterms.dateAccepted2019-12-18
dc.date.updated2020-07-24T06:30:15Z
gro.hasfulltextNo Full Text
gro.griffith.authorRoss, Allen G.


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