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dc.contributor.authorChan, Chris HH
dc.contributor.authorKi, Katrina K
dc.contributor.authorChu, Ian Y
dc.contributor.authorRolls, Joshua
dc.contributor.authorMorris, Sasha
dc.contributor.authorLee, Talvin J
dc.contributor.authorBindorfer, Stefan
dc.contributor.authorPauls, Jo P
dc.contributor.authorIdachi, Iki
dc.contributor.authorFraser, John F
dc.date.accessioned2021-05-11T23:28:19Z
dc.date.available2021-05-11T23:28:19Z
dc.date.issued2020
dc.identifier.issn1538-943X
dc.identifier.doi10.1097/MAT.0000000000001222
dc.identifier.urihttp://hdl.handle.net/10072/395883
dc.description.abstractThe development of adult use right ventricular assist devices (RVADs) and pediatric left ventricular assist devices (pediatric LVADs) have significantly lagged behind compared to adult use left ventricular assist devices (LVADs). The HeartWare ventricular assist device (HVAD) intended to be used for adult's systemic support, is increasingly used off-label for adult pulmonary and pediatric systemic support. Due to different hemodynamics and physiology, however, the HVAD's hemocompatibility profiles can be drastically different when used in adult pulmonary circulation or in children, compared to its intended usage state, which could have a direct clinical and developmental relevance. Taking these considerations in mind, we sought to conduct in vitro hemocompatibility testing of HVAD in adult systemic, pediatric systemic and adult pulmonary support conditions. Two HVADs coupled to custom-built blood circulation loops were tested for 6 hours using bovine blood at 37°C under adult systemic, pediatric systemic, and adult pulmonary flow conditions (flow rate = 5.0, 2.5, and 4.5 L/min; differential pressure = 100, 69, and 20 mm Hg, respectively). Normalized index of hemolysis for adult systemic, pediatric systemic, and adult pulmonary conditions were 0.0083, 0.0039, and 0.0017 g/100 L, respectively. No significant difference was seen in platelet activation for these given conditions. High molecular weight von Willebrand factor multimer degradation was evident in all conditions (p < 0.05). In conclusion, alterations in the usage mode produce substantial differences in hemocompatibility of the HVAD. These findings would not only have clinical relevance but will also facilitate future adult use RVAD and pediatric LVAD development.
dc.description.peerreviewedYes
dc.description.sponsorshipUniversity of Queensland - Prince Charles Hospital Foundation
dc.description.sponsorshipThe Prince Charles Hospital Foundation
dc.languageEnglish
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.ispartofpagefrom270
dc.relation.ispartofpageto275
dc.relation.ispartofissue3
dc.relation.ispartofjournalASAIO Journal
dc.relation.ispartofvolume67
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchcode0903
dc.titleIn vitro Hemocompatibility Evaluation of the HeartWare Ventricular Assist Device Under Systemic, Pediatric and Pulmonary Support Conditions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChan, CHH; Ki, KK; Chu, IY; Rolls, J; Morris, S; Lee, TJ; Bindorfer, S; Pauls, JP; Idachi, I; Fraser, JF, In vitro Hemocompatibility Evaluation of the HeartWare Ventricular Assist Device Under Systemic, Pediatric and Pulmonary Support Conditions, ASAIO Journal, 37 (3), pp. 270-275, 2021
dc.date.updated2020-07-29T00:08:46Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2021 Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in ASAIO Journal, 67 (3), pp. 270-275, 2020. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal link for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorFraser, John F.
gro.griffith.authorPauls, Jo P.
gro.griffith.authorChan, Hoi Houng


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